A0A8D2EL63 · A0A8D2EL63_THEGE
- ProteinLactosylceramide 4-alpha-galactosyltransferase
- GeneA4GALT
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids353 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + H+ + UDPThis reaction proceeds in the forward direction.
- beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H+ + UDPThis reaction proceeds in the forward direction.
Pathway
Glycolipid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Molecular Function | galactosyltransferase activity | |
Biological Process | glycosphingolipid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLactosylceramide 4-alpha-galactosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Theropithecus
Accessions
- Primary accessionA0A8D2EL63
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Single-pass type II membrane protein
Membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-42 | Helical | ||||
Sequence: VCTLFIIGFKFTFFVSIMIYWHV |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 222-349 | Alpha 1,4-glycosyltransferase | ||||
Sequence: AFERRHEFMALCMRDFVDHYNGWIWGHQGPQLLTRVFKKWCSIRSLAESHACRGVTTLPPEAFYPIPWQDWKKYFEDINPEELPQLFNATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHKAM |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)40,422
- Last updated2022-01-19 v1
- ChecksumAF3F3D00484C2C2F
Keywords
- Technical term