A0A8D1ULG8 · A0A8D1ULG8_PIG
- ProteinMidkine
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids564 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | growth factor activity | |
Molecular Function | heparin binding | |
Biological Process | positive regulation of cell division |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameMidkine
- Short namesMK
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionA0A8D1ULG8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MDFFSFLLFFFFAGEIFL | ||||||
Chain | PRO_5034223265 | 19-564 | Midkine | |||
Sequence: QKQGGVPGSPQAGDPNTADPDPDSLQGVPVPLWCGVLGAARDLTSAWLPRSSRLGEEPISSCFPLPAGTVTMKVKEVERGEAWLLGPLGPVALGKPPPTPRPKLRSLFRGSDEVVPEAPGSEGLGICSCCRAGSGTSLRRLLSAPNPGLRAPPPSTPQPPTPPTCAWRKAEGLGTRDPCASPGFPGPAPPTSSRASPRTLSEAFEARAGTSSPASKGPWEMEQGLDGVKCCTRASGAGAAHRLPAGPAPRPVTHPGLRAPSRWPPKASWPWREAGGQRGEGTASRSPGPTEPVVGGQGQGVPGPDGSPGPGELGVWGWRVWGRLAGSWGRGWGRGAGAKAGTAGSGGGAGLRGGGGTFLGGGGEGAGAHVTGSDRFWRQKGPRRPERDGPGAGGSEAAPAESEMQRRGFLLLALFALLALTDAVAKKKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRVRCRVPCNWKKEFGADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 23-42 | Disordered | ||||
Sequence: GVPGSPQAGDPNTADPDPDS | ||||||
Region | 158-239 | Disordered | ||||
Sequence: RLLSAPNPGLRAPPPSTPQPPTPPTCAWRKAEGLGTRDPCASPGFPGPAPPTSSRASPRTLSEAFEARAGTSSPASKGPWEM | ||||||
Compositional bias | 165-182 | Pro residues | ||||
Sequence: PGLRAPPPSTPQPPTPPT | ||||||
Region | 257-333 | Disordered | ||||
Sequence: AAHRLPAGPAPRPVTHPGLRAPSRWPPKASWPWREAGGQRGEGTASRSPGPTEPVVGGQGQGVPGPDGSPGPGELGV | ||||||
Region | 373-418 | Disordered | ||||
Sequence: GGTFLGGGGEGAGAHVTGSDRFWRQKGPRRPERDGPGAGGSEAAPA | ||||||
Compositional bias | 394-408 | Basic and acidic residues | ||||
Sequence: FWRQKGPRRPERDGP | ||||||
Domain | 445-501 | Pleiotrophin/Midkine N-terminal | ||||
Sequence: KKDKVKKGGPGSECAEWTWGPCTPSSKDCGVGFREGTCGAQTQRVRCRVPCNWKKEF | ||||||
Domain | 502-563 | Pleiotrophin/Midkine C-terminal | ||||
Sequence: GADCKYKFESWGACDGGTGTKARQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGK |
Sequence similarities
Belongs to the pleiotrophin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length564
- Mass (Da)58,417
- Last updated2022-01-19 v1
- Checksum13AEF2A0C40B5271
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 165-182 | Pro residues | ||||
Sequence: PGLRAPPPSTPQPPTPPT | ||||||
Compositional bias | 394-408 | Basic and acidic residues | ||||
Sequence: FWRQKGPRRPERDGP |