A0A8D0FPU5 · A0A8D0FPU5_STROC

Function

function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation.

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionprotein-glutamine gamma-glutamyltransferase activity
Biological Processkeratinization
Biological Processpeptide cross-linking

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-glutamine gamma-glutamyltransferase K
  • EC number
  • Alternative names
    • Epidermal TGase
    • Transglutaminase K
    • Transglutaminase-1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Strigiformes > Strigidae > Strix

Accessions

  • Primary accession
    A0A8D0FPU5

Proteomes

Subcellular Location

Membrane
; Lipid-anchor

PTM/Processing

Keywords

Interaction

Subunit

Interacts with PLAAT4.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-35Disordered
Region54-189Disordered
Region295-316Disordered
Domain482-575Transglutaminase-like
Region639-732Disordered
Compositional bias644-677Polar residues
Compositional bias702-728Polar residues
Region913-955Disordered

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    955
  • Mass (Da)
    102,998
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    E8A4DE54E79A791FFEE6F6CFFF2429BD
MPDADPRLDAGRWAAASFRPRGAPSAPTPRPRRGFWRRLGGCCSCCGCCRRGNEDWEPPPGEVPGRRPPQPLRPGQCQGGGGGEQQRFRGSPGREVAVSGLPREGKSGFGAPQGGKGRFRGSPGRERAVSGLPREGRGGFGAPRGGKERFWGSPGREVAVSGLPREGKSGFGAPQGGKERFRGSPGREGAVLGPPITRFWRFRGWDSRRVFTACPFSPPPGLLAPRGLVVASSADRLAHHTSEFACSRPVLRRGQRFALRVLLPRPFDPDGDSLCPNPQVAKGTHVLIPLGETSATGWTAEEEEEEEEGAEHPGGPALRLCLAAPPDAPIGRYCLSVKTRTGAGEYAAPFDDANDFFLLFNPWCPDDNVYMEKTSDLNEYVLNETGRIFYGTEDQIAERSWNYGQFDAGVLEACLYILDRRGMPHSARGDPVMVSRVVSAMVNSLDDNGVLVGNWTGDYAQGTNPSAWAGSVDILRAYHGAGAPVRYGQCWVFAGVMTTVLRCLGLPTRTVTNYNSAHDTDVSLTTDIYFDENMRPLERLNTDSVWNFHVWNDCWMKRPDLPNGYDGWQVVDATPQETSSGLFCCGPCSVTAVKNGEVFLKYDTPFVFAEVNSDKVYWQRQPSGAFAVVHVEEGAIGRRISTLGAGSDPTQPNNPTMTQHDPTTQRDPMTQPMTVDPSSPHLDPHDPTTPWRHPLTPPEERRAVSTATSHGSRPRTRGTPSSGEVTVTVGAGXNEGLEPRTLRLRLALAAVRYTGVSGAPFRQEQHRRAVPPGQEETVTMTVAYAEYGPHVGDQDALRLTVAGAVEETGQVVAKELRVRLHTPELTLTLLAPAVVGQETPVQVVFQNPLPEPLSGATLRMEGAGISCPKPLPMGSVGAGQTVRLRQAVVPLRPGRRRLVAALESPRLGPLHGVLQLDVAPAPAGSTGSTGNTGSPPRRPRRARRRTPPPTGSTGG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias644-677Polar residues
Compositional bias702-728Polar residues

Keywords

Genome annotation databases

Similar Proteins

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