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A0A8C9NC08 · A0A8C9NC08_SERCA

Function

function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.

Features

Showing features for binding site.

149550100150200250300350400450
TypeIDPosition(s)Description
Binding site253-260ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentspindle pole
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule severing ATPase activity
Biological Processcell division
Biological Processmicrotubule severing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Fringillidae > Carduelinae > Serinus

Accessions

  • Primary accession
    A0A8C9NC08

Proteomes

Subcellular Location

Cytoplasm
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Keywords

Interaction

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region90-189Disordered
Compositional bias144-189Basic and acidic residues
Domain245-387AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    495
  • Mass (Da)
    56,264
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    964D1AB197566228C1EE541A73D8021D
MLNMSLVMIIENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVRDTYLQQKWQQVWQEISVEAKHVKDIMKTLESFKLDNTPLKASQQELPAHDAEVWSLPVPAERRPSPGPRKRQSAPCSDCRGHSNRVSAAARGSHRPSSRNPSDKGKAVRSREKKDQQNKGKEEKNKSTSEISESEPKKFDSTGYDKDLVEALERDIISQNPNIRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGATENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLKINLRELELADDVDLANIAEKMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLPRDEMHMPTTMEDFEIALKKVSKSVSAADIEKYEKWIVEFGSC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias144-189Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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