A0A8C9MC76 · A0A8C9MC76_PANTA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePLCB1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1216 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 331 | ||||
Binding site | 332 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 361 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 363 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 378 | ||||
Binding site | 412 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Pantherinae > Panthera
Accessions
- Primary accessionA0A8C9MC76
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 471-537 | Disordered | |||
Compositional bias | 480-500 | Polar residues | |||
Compositional bias | 507-521 | Acidic residues | |||
Domain | 540-656 | PI-PLC Y-box | |||
Domain | 656-784 | C2 | |||
Region | 835-895 | Disordered | |||
Compositional bias | 851-875 | Polar residues | |||
Compositional bias | 945-982 | Basic and acidic residues | |||
Region | 945-995 | Disordered | |||
Region | 1072-1095 | Disordered | |||
Region | 1168-1216 | Disordered | |||
Compositional bias | 1195-1216 | Basic and acidic residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,216
- Mass (Da)138,717
- Last updated2022-01-19 v1
- MD5 Checksum40769319B66C30816AF9CAF9045B09FB
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C9MDA7 | A0A8C9MDA7_PANTA | PLCB1 | 1173 | ||
A0A8C9KKZ7 | A0A8C9KKZ7_PANTA | PLCB1 | 1136 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 480-500 | Polar residues | |||
Compositional bias | 507-521 | Acidic residues | |||
Compositional bias | 851-875 | Polar residues | |||
Compositional bias | 945-982 | Basic and acidic residues | |||
Compositional bias | 1195-1216 | Basic and acidic residues | |||
Keywords
- Technical term