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A0A8C9MC76 · A0A8C9MC76_PANTA

Function

function

Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site331
Binding site332Ca2+ (UniProtKB | ChEBI)
Binding site361Ca2+ (UniProtKB | ChEBI)
Binding site363Ca2+ (UniProtKB | ChEBI)
Active site378
Binding site412Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentnuclear speck
Cellular Componentpostsynaptic cytosol
Cellular Componentprotein-containing complex
Molecular Functioncalcium ion binding
Molecular Functioncalmodulin binding
Molecular Functionenzyme binding
Molecular FunctionGTPase activator activity
Molecular Functionlamin binding
Molecular Functionphosphatidylinositol phospholipase C activity
Molecular Functionphosphatidylinositol-4,5-bisphosphate binding
Biological Processactivation of meiosis involved in egg activation
Biological Processcerebral cortex development
Biological Processfat cell differentiation
Biological ProcessG2/M transition of mitotic cell cycle
Biological Processglutamate receptor signaling pathway
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processinterleukin-1-mediated signaling pathway
Biological Processinterleukin-12-mediated signaling pathway
Biological Processinterleukin-15-mediated signaling pathway
Biological Procession channel modulating, G protein-coupled receptor signaling pathway
Biological Processligand-gated ion channel signaling pathway
Biological Processlipid catabolic process
Biological Processmemory
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of monocyte extravasation
Biological Processphosphatidylinositol metabolic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
Biological Processpositive regulation of acrosome reaction
Biological Processpositive regulation of CD24 production
Biological Processpositive regulation of developmental growth
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of embryonic development
Biological Processpositive regulation of G1/S transition of mitotic cell cycle
Biological Processpositive regulation of insulin secretion
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of myoblast differentiation
Biological Processpostsynaptic modulation of chemical synaptic transmission
Biological Processregulation of establishment of endothelial barrier
Biological Processregulation of fertilization
Biological Processregulation of G protein-coupled receptor signaling pathway
Biological Processregulation of retrograde trans-synaptic signaling by endocanabinoid
Biological Processrelease of sequestered calcium ion into cytosol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      PLCB1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Pantherinae > Panthera

Accessions

  • Primary accession
    A0A8C9MC76

Proteomes

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region471-537Disordered
Compositional bias480-500Polar residues
Compositional bias507-521Acidic residues
Domain540-656PI-PLC Y-box
Domain656-784C2
Region835-895Disordered
Compositional bias851-875Polar residues
Compositional bias945-982Basic and acidic residues
Region945-995Disordered
Region1072-1095Disordered
Region1168-1216Disordered
Compositional bias1195-1216Basic and acidic residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,216
  • Mass (Da)
    138,717
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    40769319B66C30816AF9CAF9045B09FB
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNDSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKPFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMDLEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSLASDPGKLNHRPPSSEELEGDNPGKEFDTPL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C9MDA7A0A8C9MDA7_PANTAPLCB11173
A0A8C9KKZ7A0A8C9KKZ7_PANTAPLCB11136

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias480-500Polar residues
Compositional bias507-521Acidic residues
Compositional bias851-875Polar residues
Compositional bias945-982Basic and acidic residues
Compositional bias1195-1216Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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