A0A8C9D7T1 · A0A8C9D7T1_PANLE
- ProteinMitogen-activated protein kinase
- GeneMAPK3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids311 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by threonine and tyrosine phosphorylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 43 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytoskeleton | |
Cellular Component | early endosome | |
Cellular Component | focal adhesion | |
Cellular Component | Golgi apparatus | |
Cellular Component | late endosome | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase activity | |
Biological Process | caveolin-mediated endocytosis | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of cytoskeleton organization | |
Biological Process | regulation of early endosome to late endosome transport | |
Biological Process | regulation of Golgi inheritance | |
Biological Process | regulation of stress-activated MAPK cascade |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Pantherinae > Panthera
Accessions
- Primary accessionA0A8C9D7T1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 13-262 | Protein kinase | |||
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)35,947
- Last updated2022-01-19 v1
- MD5 Checksum7D1A3335FE9693C9BC235104AF3E288C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C8XP37 | A0A8C8XP37_PANLE | MAPK3 | 379 | ||
A0A8C8XKR3 | A0A8C8XKR3_PANLE | MAPK3 | 335 |
Keywords
- Technical term