A0A8C8WFD9 · A0A8C8WFD9_PANLE

  • Protein
    L-dopachrome tautomerase
  • Gene
    DCT
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pigment biosynthesis; melanin biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmelanosome membrane
Cellular Componentplasma membrane
Molecular Functiondopachrome isomerase activity
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity
Biological Processcell development
Biological Processdevelopmental pigmentation
Biological Processmelanin biosynthetic process from tyrosine
Biological Processpositive regulation of neuroblast proliferation
Biological Processresponse to blue light
Biological Processventricular zone neuroblast division

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-dopachrome tautomerase
  • EC number
  • Alternative names
    • L-dopachrome Delta-isomerase
    • Tyrosinase-related protein 2

Gene names

    • Name
      DCT

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Pantherinae > Panthera

Accessions

  • Primary accession
    A0A8C8WFD9

Proteomes

Subcellular Location

Melanosome membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane467-491Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_503449906224-517L-dopachrome tautomerase

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain211-228Tyrosinase copper-binding
Domain389-400Tyrosinase copper-binding

Sequence similarities

Belongs to the tyrosinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    517
  • Mass (Da)
    59,245
  • Last updated
    2022-01-19 v1
  • Checksum
    EDB42BC9B6BF2610
MSPLGWGLLLSCLGCGILPGAWAQFPRVCMTVNNLVSKECCPPLGEDPDNICGYLEGRGQCVEVQADTRPWSGPYILRNQDDREWWPRKFFHRTCRCRGHFYGYHCGFCRFGWTGHDCNERKPLVVRKNIHSLTLQEREQFLDALDLAKNTTHPDYVITTQHWLGLLGPNGTQPQIANSSIYDFFVWLHYYSVRDTLLGPGRPYKAIDFSHQGPAFVTWHRYHLLWLERDLQHLIGNESFALPYWNFATGKNECDVCTDQLFGAARQDDPTLISRNSRFSSWEVICDSLDDYNRRVTLCNGTSEGLLRRNQVGRNSEKLPTLKDVQDCLSLKKFDNPPFFQNSTFSFRNALEGFDKANGILDSQMMSLHNLVHSFLNGTSALPHSAANDPIFVVLHSFTDAIFDEWMKRSNPPVDAWPQELAPIGHNRMYNMVPFFPPVTNVEFFLTADQLGYSYAIDLPVEETPGWSTTLLVVMGMLVALVGLFVLLFFLQYRRLRKGYTPLVETHLSNKKYTEEA

Keywords

Genome annotation databases

Similar Proteins

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