A0A8C8WFD9 · A0A8C8WFD9_PANLE
- ProteinL-dopachrome tautomerase
- GeneDCT
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids517 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
Catalytic activity
- L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
Cofactor
Pathway
Pigment biosynthesis; melanin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | melanosome membrane | |
Cellular Component | plasma membrane | |
Molecular Function | dopachrome isomerase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | cell development | |
Biological Process | developmental pigmentation | |
Biological Process | melanin biosynthetic process from tyrosine | |
Biological Process | positive regulation of neuroblast proliferation | |
Biological Process | response to blue light | |
Biological Process | ventricular zone neuroblast division |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-dopachrome tautomerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Pantherinae > Panthera
Accessions
- Primary accessionA0A8C8WFD9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Melanosome membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 467-491 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-23 | ||||
Chain | PRO_5034499062 | 24-517 | L-dopachrome tautomerase | ||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 211-228 | Tyrosinase copper-binding | |||
Domain | 389-400 | Tyrosinase copper-binding | |||
Sequence similarities
Belongs to the tyrosinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length517
- Mass (Da)59,245
- Last updated2022-01-19 v1
- ChecksumEDB42BC9B6BF2610
Keywords
- Technical term