A0A8C6X675 · A0A8C6X675_NAJNA

  • Protein
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionriboflavin transmembrane transporter activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family G member 2
    • Urate exporter

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Elapinae > Naja

Accessions

  • Primary accession
    A0A8C6X675

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane515-540Helical
Transmembrane552-574Helical
Transmembrane643-663Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_503417494816-672Broad substrate specificity ATP-binding cassette transporter ABCG2

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain56-302ABC transporter

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    672
  • Mass (Da)
    74,883
  • Last updated
    2022-01-19 v1
  • Checksum
    A298B0C21C8E9B2A
LFPSLLLGLLCGCLCVFRRQGILVGGEVFGDCHVCVHVESGLWVLCEFCCMYTAYIRTMTIKNSINQYIYSKNIQSNRLLLFYSGVMKPGLNAILGPTGCGKSSLLDILSTRKDPQGLSGDILLDGMGLPTHFKCMSGYVVQDDIVMGTLTVRENLMFSAALRLPLSMSKYEKNQRVDQVLKELDLAKVADTKVGTYFSRGVSGGERKRTSIGLELITNPKVLFLDEPTTGLDASTANAVLLLLKRMSLQGKTIIFSIHQPRYSIFKLFDSLTLLAAGRLLYHGPADNALPYFKSLGFVCEPYNNPADFFLDIINGDSSAVATSKMAIHSAVLEATEREQETIALTLAVQFSKCNFYKKMLEELDAMSKEQKRLGTMIKGLPYSTPFLHQLKWLSKRTFKNLIGNPQNSTAQVNKVFCFIVVVHMFSLSNLKILGFSCRVGALFFLATNQVLNSITTVELFISEKRIFIHEYISGYYRVSAYFFSKLIADMMPMRTLPGIILTSLNYFTIGFKPVLASFFIMMLTIILIAYASSSLALAVATGQNITSVANLLINICFVFMIVFSGILVNLTTITPSLLWLEYFSIPRYGLNALQINEFTGLRFCNETPEGVNVTCVSTTAFTVCTGEDYLEMQGIGTTAWDLWQNHVALICMTIIFLTIAYLKLKFLKKYT

Keywords

Genome annotation databases

Similar Proteins

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