A0A8C5XHU5 · A0A8C5XHU5_MICMU
- ProteinDihydropyrimidine dehydrogenase [NADP(+)]
- GeneDPYD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1025 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Catalytic activity
- 5,6-dihydrothymine + NADP+ = H+ + NADPH + thymineThis reaction proceeds in the backward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.
Pathway
Amino-acid biosynthesis; beta-alanine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | uracil binding | |
Biological Process | beta-alanine biosynthetic process | |
Biological Process | CMP catabolic process | |
Biological Process | dCMP catabolic process | |
Biological Process | dUMP catabolic process | |
Biological Process | purine nucleobase catabolic process | |
Biological Process | thymidine catabolic process | |
Biological Process | thymine catabolic process | |
Biological Process | UMP catabolic process | |
Biological Process | uracil catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropyrimidine dehydrogenase [NADP(+)]
- EC number
- Short namesDHPDHase ; DPD
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Cheirogaleidae > Microcebus
Accessions
- Primary accessionA0A8C5XHU5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 944-976 | 4Fe-4S ferredoxin-type | ||||
Sequence: VVAMIDEEMCINCGKCYMTCNDSGYQAIQFHPE | ||||||
Domain | 978-1007 | 4Fe-4S ferredoxin-type | ||||
Sequence: HLPTITDACTGCTLCLSVCPIIDCIKMVSR |
Sequence similarities
Belongs to the dihydropyrimidine dehydrogenase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,025
- Mass (Da)111,758
- Last updated2022-01-19 v1
- Checksum5001B9625773B354
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C5UP95 | A0A8C5UP95_MICMU | DPYD | 1015 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
ABDC03002797 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
ABDC03002798 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
ABDC03002799 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |