A0A8C5AG46 · A0A8C5AG46_GADMO

Function

function

This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. Also, involved in the degradation of oxidized and glycated proteins.

Catalytic activity

  • Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.
    EC:3.4.19.1 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acylamino-acid-releasing enzyme
  • EC number
  • Alternative names
    • Acyl-peptide hydrolase
    • Acylaminoacyl-peptidase

Gene names

    • Name
      apeh

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Zeiogadaria > Gadariae > Gadiformes > Gadoidei > Gadidae > Gadus

Accessions

  • Primary accession
    A0A8C5AG46

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_503483868321-700Acylamino-acid-releasing enzyme

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain152-276Acylamino-acid-releasing enzyme N-terminal
Domain490-698Peptidase S9 prolyl oligopeptidase catalytic

Sequence similarities

Belongs to the peptidase S9C family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    700
  • Mass (Da)
    77,429
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    B01983B5B2B5D9BF09EA35B7E0D55FBB
MNRSLFFVRHLLSMSRHVSSSAACCQVTTSPDEICKLYRKLSLFPALSRADVGPVITSQYGGKYSNIYTEWSQCDLERNENVKFCKQYIVFHDEKTVVYSGPSGNCTEIKGEVLSRDSPSGEMKAVVRECSVKGEEKQFLEVRRCLLLVTHLLYVAERKRPKAESFFQSPESSSTGDEDEMGTKLETKEKTKGMQFVFYEDWGEALVGKSCPVLCVLDIEGNNVSLLDGVPEDISPGQAFWAPGDTGVVFVGWRHEPFRLGLKYCPNRQSSLFYVDLTGGMCEQLSSGDSAVCSPRLSPDQCRIVYLECGIFGPHMQCSRLCMYDWYTKKSSVVVDVVKRPGEDGFTGIYSSQLSPQCWSADSQRVLIACPQRSRKDLLVVDISTGGITSLTASESTDTSSTVGFLPAKDSQEDVSWVTLEEAQPQKDISWQILTLSPPTDQDNSQYPGLDFEALLIKPKDAQEGVKLPLVVIPHGGPHSVIVAEWLLSPSVLCRMGFAVLLVNYRGSIGYGQDNVLSLPGNVGSQDVQDVHFAVESVLKDGGFDKQKVALSGGSHGGFLACHLIGQYPGFYKACVARNPVTNLASMIGSTDIPDWCMVESGYNYSADCLPDAAIWEQMLSKSPIKHIAKVKTPVLLMLGEEDKRVPNKQGIEYYRALKARQLPVQLFWYPGNNHSLSKVDAESDGFMNVALWLVQHLCR

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C4ZVY3A0A8C4ZVY3_GADMOapeh727
A0A8C5CXS6A0A8C5CXS6_GADMOapeh714
A0A8C5D479A0A8C5D479_GADMOapeh668
A0A8C5F4E7A0A8C5F4E7_GADMOapeh727
A0A8C5CLP7A0A8C5CLP7_GADMOapeh679
A0A8C5AZ45A0A8C5AZ45_GADMOapeh712
A0A8C5FUH7A0A8C5FUH7_GADMOapeh715

Keywords

Genome annotation databases

Similar Proteins

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