A0A8C4LA28 · A0A8C4LA28_EQUAS

  • Protein
    Protein phosphatase 1 regulatory subunit 15A
  • Gene
    PPP1R15A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentprotein phosphatase type 1 complex
Molecular Functionprotein phosphatase regulator activity
Biological Processapoptotic process
Biological Processpositive regulation of phosphoprotein phosphatase activity
Biological Processresponse to endoplasmic reticulum stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein phosphatase 1 regulatory subunit 15A
  • Alternative names
    • Growth arrest and DNA damage-inducible protein GADD34

Gene names

    • Name
      PPP1R15A

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    A0A8C4LA28

Subcellular Location

Endoplasmic reticulum membrane
; Peripheral membrane protein
Mitochondrion outer membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-32
ChainPRO_503411717233-707Protein phosphatase 1 regulatory subunit 15A

Keywords

Interaction

Subunit

Interacts with PPP1CA. Interacts with EIF2S1. Interacts with PCNA. Interacts with LYN and KMT2A/MLL1. Interacts with PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1. Interacts with NOX4.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region66-103Disordered
Compositional bias75-98Basic and acidic residues
Region116-171Disordered
Compositional bias153-168Basic and acidic residues
Region187-540Disordered
Compositional bias219-242Basic and acidic residues
Compositional bias307-324Acidic residues
Compositional bias349-365Acidic residues
Compositional bias394-412Acidic residues
Compositional bias441-463Acidic residues
Compositional bias488-504Acidic residues
Domain584-655Protein phosphatase 1 regulatory subunit 15A/B C-terminal

Sequence similarities

Belongs to the PPP1R15 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    707
  • Mass (Da)
    77,415
  • Last updated
    2022-01-19 v1
  • Checksum
    4E29EB383C39A275
MAPGQAPHHPSPWRDAHPFFLLSPLMGLLSWAWSHLRGPGSPEPWLAEAVTSAHRAQAGLEGVTKASLATHHAPWGRRPQEEGGDPGAAEEDREASWGACPDWKANTSPLEAWGLSDDEGEEEATEVPREQGSEFIDGRPALRSPSLLIRTLQEDPPREEESAEGGVAEDKEVVTFSFPPFHWECCPGVEEEKEGDSINKESPRTSTCPLSPGSKPRAWVDCSREEENQATEEERRESREATKTSVSPSTAGSQPRPWERCSGAESEEEDDEKAERGEADPEPLSSVLAQRPLLRTRQHQPSKITEEEDEEQDEFSDSGAAEEEGEAEGPSSIPSTSAFLRAWVYRPGEDTEEEEEEDELSDSGAAEEEGEAKGPSSIPSTSAFLRAWVYRPGEDTEEEEEEEEDELSDSGAAEEEGEAKGPSSIPSTSAFLRAWVYRPGEDTEEEEEEEEDELSDSGAAEEEGEAEGPSSIPPTSAFLRAWVYRPGEDTEEEEENEDEDDSEAAVSGPSPSLQAQSALLRPGEETEGGEAAEEWGEAEPSPFRVAIYLPGEKAPPPWTPPRLPLRLQRRLKSTETPTRDLEPETPLKARKVCFSEKVTIHFLVVWAGPAQAARRGPWEQLARDRSRFAHRIARAQEELGPCLTPAARARAWARLRNPPASLATIPAATHAFQTSSIQAMPLSHAVASPSPPYVSISPCLDLSGRRG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias75-98Basic and acidic residues
Compositional bias153-168Basic and acidic residues
Compositional bias219-242Basic and acidic residues
Compositional bias307-324Acidic residues
Compositional bias349-365Acidic residues
Compositional bias394-412Acidic residues
Compositional bias441-463Acidic residues
Compositional bias488-504Acidic residues

Genome annotation databases

Similar Proteins

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