A0A8C4K299 · A0A8C4K299_DRONO
- Protein3-hydroxyisobutyrate dehydrogenase
- GeneHIBADH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids317 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+
Pathway
Amino-acid degradation; L-valine degradation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 21-49 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 84-85 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 89 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 115 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 190 | ||||
Binding site | 265 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | 3-hydroxyisobutyrate dehydrogenase activity | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Biological Process | valine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-hydroxyisobutyrate dehydrogenase
- EC number
- Short namesHIBADH
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Palaeognathae > Casuariiformes > Dromaiidae > Dromaius
Accessions
- Primary accessionA0A8C4K299
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5034751168 | 19-317 | 3-hydroxyisobutyrate dehydrogenase | ||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 23-181 | 6-phosphogluconate dehydrogenase NADP-binding | |||
Domain | 184-310 | 3-hydroxyisobutyrate dehydrogenase-like NAD-binding | |||
Sequence similarities
Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length317
- Mass (Da)33,494
- Last updated2022-01-19 v1
- ChecksumB525C9216B4DDDAC