Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

A0A8C4FJY2 · A0A8C4FJY2_9TELE

Function

function

Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.

Catalytic activity

  • 3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA
    This reaction proceeds in the forward direction.
  • 3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA
    This reaction proceeds in the forward direction.
  • 7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)
  • an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.16 (UniProtKB | ENZYME | Rhea)
  • butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.155 (UniProtKB | ENZYME | Rhea)
  • choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.176 (UniProtKB | ENZYME | Rhea)
  • propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentperoxisome
Molecular Functionacyltransferase activity, transferring groups other than amino-acyl groups
Molecular Functionlipid binding
Biological Processlipid transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sterol carrier protein 2
  • EC number
  • Alternative names
    • Acetyl-CoA C-myristoyltransferase
    • Non-specific lipid-transfer protein
    • Propanoyl-CoA C-acyltransferase
    • SCP-2/3-oxoacyl-CoA thiolase
    • SCP-2/thiolase

Gene names

    • Name
      LOC114789332

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Clupei > Clupeiformes > Denticipitoidei > Denticipitidae > Denticeps

Accessions

  • Primary accession
    A0A8C4FJY2

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-224Thiolase N-terminal
Domain263-379Thiolase C-terminal
Domain420-521SCP2

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    530
  • Mass (Da)
    57,261
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    B4FA3BB66524ED55E5ACC672534FE581
MAPNVVVPVFEKPGARDADYPDMAKEAGERALADAGIPYSAIKQACVGYVYGDSTCGQRAIYHSLGLTGIPIVNVNNNCSTGSTALFMARQLVQGGLADCVLALGFEKMDRGSLSSKYMDRTNPMDKHMEVMINRYGLAAAPAAPQMFGNAGREHMERYGTKPEHFAKIAWKNHKHSTNNPYSQFRDEYSLDQVLGSRRVFQFLTLLQCCPTSDGAGAAILASEDFVRRYGLEDKAVEIIAQEMVTDLSSTFEENSCIKMVGYDMTRVAAQKCFQKAGLSPSDVNVIELHDCFSANELITYEALGLCPEGKAGELIDLGHNTYGGKWVVNPSGGLISKGHPLGATGLAQCAELCWQLRGVAGRRQVPGAKVALQHNIGLGGAVVVTLYRMGFPQDTRRAIAALPTSASNDLKTFKSYAVFNEISKRLEQEGEGFVKKIGGIFAFKVKDGPGGKEALWVVDVKNGKGSVDNDANKKADCTISMSDEDLLALMMGKMNPQTAFFQGKLKITGNMGMAMKLQNLQVTAGKAKL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C3Z6D2A0A8C3Z6D2_9TELELOC114789332559
A0A8C3Z6E0A0A8C3Z6E0_9TELELOC114789332538

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help