A0A8C3SVL1 · A0A8C3SVL1_CHESE

Function

function

Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.

Catalytic activity

  • 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.95 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
    This reaction proceeds in the forward direction.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site258-261substrate
Binding site283-284substrate
Active site345Phosphocysteine intermediate
Binding site345-351substrate

GO annotations

AspectTerm
Cellular Componentearly endosome membrane
Molecular Functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Molecular Functionphosphatidylinositol-3-phosphate phosphatase activity
Biological Processphosphatidylinositol dephosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
  • EC number
  • Alternative names
    • Myotubularin-related protein 2
    • Phosphatidylinositol-3-phosphate phosphatase

Organism names

Accessions

  • Primary accession
    A0A8C3SVL1

Proteomes

Subcellular Location

Cytoplasm
Early endosome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_503405780617-571Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain133-508Myotubularin phosphatase
Domain314-361Tyrosine specific protein phosphatases
Region544-571Disordered
Compositional bias546-571Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    571
  • Mass (Da)
    66,073
  • Last updated
    2022-01-19 v1
  • Checksum
    3152C34DED0943DF
MMVSELLLFSFFHLLAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLEIVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYREVFPENGWKVYDPILEYRRQGIPNESWRITKINERYELCDTYPAILVVPVNIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQSIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSMLILDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNDCFLMIILDHLYSCLFGTFLCSSEQQRVKESLPKKTLSLWSYINSQLEDFTNPLYVCYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPVHSRYKELLAKRAELQKKVEELQREITNRSTSSSERAGSPAQCVTPVQTVV

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C3SQL2A0A8C3SQL2_CHESE643
A0A8C3SRQ6A0A8C3SRQ6_CHESE583
A0A8C3SS37A0A8C3SS37_CHESE602
A0A8C3SV56A0A8C3SV56_CHESE571
A0A8C3SUK9A0A8C3SUK9_CHESE577
A0A8C3SV00A0A8C3SV00_CHESE569
A0A8C3STP2A0A8C3STP2_CHESE641

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias546-571Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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