A0A8C2V305 · A0A8C2V305_CHILA

Function

function

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site42-48GTP (UniProtKB | ChEBI)
Active site43Proton acceptor
Binding site43Mg2+ (UniProtKB | ChEBI)
Binding site43substrate
Binding site43-46IMP (UniProtKB | ChEBI)
Binding site68-71IMP (UniProtKB | ChEBI)
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site70-72GTP (UniProtKB | ChEBI)
Active site71Proton donor
Binding site197IMP (UniProtKB | ChEBI)
Active site208
Binding site211IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site290IMP (UniProtKB | ChEBI)
Binding site305IMP (UniProtKB | ChEBI)
Binding site365-371substrate
Binding site369IMP (UniProtKB | ChEBI)
Binding site371GTP (UniProtKB | ChEBI)
Binding site397-399GTP (UniProtKB | ChEBI)
Binding site479-482GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase isozyme 1
  • EC number
  • Short names
    AMPSase 1
    ; AdSS 1
  • Alternative names
    • Adenylosuccinate synthetase, basic isozyme
    • Adenylosuccinate synthetase, muscle isozyme
      (M-type adenylosuccinate synthetase
      )
    • IMP--aspartate ligase 1

Gene names

    • Name
      ADSS1
    • Synonyms
      ADSSL1

Organism names

Accessions

  • Primary accession
    A0A8C2V305

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-21Disordered

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    53,924
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    C2D3E3C00BCE92433B13C234B0A2FEA1
MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLGDSPPCPSPFPKSWYLHRPLPLLLSCSLAPHGPAVFDFHQAVDGLQEVQRQVQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSTRFKNLAHQHQSMFPSLEIDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPHNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQSRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLNEIKVGISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPLQAQNYVRFVENHVGVAVKWVGVGKSRESMIQLF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C2UXM2A0A8C2UXM2_CHILAADSS1457

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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