A0A8C2NFA9 · A0A8C2NFA9_CAPHI

Function

function

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentfilopodium membrane
Cellular Componentgrowth cone membrane
Cellular Componentperikaryon
Cellular Componentpostsynaptic density
Molecular Functioncalmodulin binding
Molecular Functionlysophosphatidic acid binding
Molecular Functionphosphatidylinositol phosphate binding
Molecular Functionphosphatidylserine binding
Biological Processaxon choice point recognition
Biological Processaxon regeneration
Biological Processregulation of growth
Biological Processtissue regeneration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuromodulin
  • Alternative names
    • Axonal membrane protein GAP-43
    • Growth-associated protein 43

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    A0A8C2NFA9

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, growth cone membrane
; Peripheral membrane protein
Synapse
Cell projection, filopodium membrane
; Peripheral membrane protein
Perikaryon
Cell projection, dendrite
Cell projection, axon
Cytoplasm
Note: Cytoplasmic surface of growth cone and synaptic plasma membranes.

Keywords

PTM/Processing

Post-translational modification

Palmitoylated. Palmitoylation is essential for plasma membrane association.

Keywords

Interaction

Subunit

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence.

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain56-77Neuromodulin gap junction N-terminal
Compositional bias60-82Basic and acidic residues
Region60-272Disordered
Compositional bias97-133Basic and acidic residues
Domain114-253Neuromodulin (GAP-43) C-terminal
Compositional bias140-162Basic and acidic residues
Compositional bias186-201Polar residues

Sequence similarities

Belongs to the neuromodulin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    27,727
  • Last updated
    2022-01-19 v1
  • Checksum
    42DEFCB9B4DC73A0
MPEAADGKGSGSHLLLSHGFGAVDHSCLRRTWPQVPSIPAAKPEAHARCACNSAIKVEKNDEDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAPAAEAEANEKDEAAVAEGTEKKEGEGSTPAEAGPKPEEKTGKAGETPSEEKKGEGAPDAATEQAAPQAPAPSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAMATAQPPTETAESSQAEXXXXXXXXXXXXXXXGGAGG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias60-82Basic and acidic residues
Compositional bias97-133Basic and acidic residues
Compositional bias140-162Basic and acidic residues
Compositional bias186-201Polar residues

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help