A0A8C2NFA9 · A0A8C2NFA9_CAPHI
- ProteinNeuromodulin
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids272 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | dendrite | |
Cellular Component | filopodium membrane | |
Cellular Component | growth cone membrane | |
Cellular Component | perikaryon | |
Cellular Component | postsynaptic density | |
Molecular Function | calmodulin binding | |
Molecular Function | lysophosphatidic acid binding | |
Molecular Function | phosphatidylinositol phosphate binding | |
Molecular Function | phosphatidylserine binding | |
Biological Process | axon choice point recognition | |
Biological Process | axon regeneration | |
Biological Process | regulation of growth | |
Biological Process | tissue regeneration |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNeuromodulin
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra
Accessions
- Primary accessionA0A8C2NFA9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Cell projection, growth cone membrane ; Peripheral membrane protein
Cell projection, filopodium membrane ; Peripheral membrane protein
Note: Cytoplasmic surface of growth cone and synaptic plasma membranes.
Keywords
- Cellular component
PTM/Processing
Post-translational modification
Palmitoylated. Palmitoylation is essential for plasma membrane association.
Keywords
- PTM
Interaction
Subunit
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 56-77 | Neuromodulin gap junction N-terminal | |||
Compositional bias | 60-82 | Basic and acidic residues | |||
Region | 60-272 | Disordered | |||
Compositional bias | 97-133 | Basic and acidic residues | |||
Domain | 114-253 | Neuromodulin (GAP-43) C-terminal | |||
Compositional bias | 140-162 | Basic and acidic residues | |||
Compositional bias | 186-201 | Polar residues | |||
Sequence similarities
Belongs to the neuromodulin family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length272
- Mass (Da)27,727
- Last updated2022-01-19 v1
- Checksum42DEFCB9B4DC73A0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 60-82 | Basic and acidic residues | |||
Compositional bias | 97-133 | Basic and acidic residues | |||
Compositional bias | 140-162 | Basic and acidic residues | |||
Compositional bias | 186-201 | Polar residues | |||