A0A8C0YXG5 · A0A8C0YXG5_CANLF
- ProteinPlatelet-activating factor acetylhydrolase
- GenePLA2G7
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids444 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H+This reaction proceeds in the forward direction.
- 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H+This reaction proceeds in the forward direction.
- 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H+This reaction proceeds in the forward direction.
- 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H+This reaction proceeds in the forward direction.
- 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 10-hydroperoxy-(8E)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 5-oxopentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 9-oxononanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 9-hydroperoxy-10E-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = butanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = glutarate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = pentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = propanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 274 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 297 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 352 | Charge relay system | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | 1-alkyl-2-acetylglycerophosphocholine esterase activity | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlatelet-activating factor acetylhydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8C0YXG5
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MLPPKLHALFCLCSCLTLVHP | ||||||
Chain | PRO_5042765627 | 22-444 | Platelet-activating factor acetylhydrolase | |||
Sequence: IDWQDLNPVAHIRSSAWANKIQALMAAASIRQSRIPKGNGSYSVGCTDLMFDYTNKGTFLRLYYPSQEDDHSDTLWIPNKEYFFGLSKYLGTPWLMGKILSFFFGSVTTPANWNSPLRTGEKYPLIVFSHGLGAFRTIYSAIGIDLASHGFIVAAIEHRDGSASATYYFKDQSAAEIGNKSWSYLQELKPGDEEIHVRNEQVQKRAKECSQALNLILDIDHGRPIKNVLDLEFDVEQLKDSIDRDKIAVIGHSFGGATVLQALSEDQRFRCGIALDAWMLPLDDAIYSRIPQPLFFINSERFQFPENIKKMKKCYSPEKERKMITIRGSVHQNFADFTFTTGKIVGYIFTLKGDIDSNVAIDLCNKASLAFLQKHLGLRKDFDQWDSLIEGKDENLMPGTNINITNEHDTLQNSPEAEKSNLD |
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)50,150
- Last updated2022-01-19 v1
- Checksum9D3FA0BA69F560FC