A0A8C0T807 · A0A8C0T807_CANLF

Function

Catalytic activity

  • S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
  • menadione + NADPH + H+ = menadiol + NADP+
  • prostaglandin D2 + NADP+ = 15-oxoprostaglandin D2 + NADPH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.196 (UniProtKB | ENZYME | Rhea)
  • prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.197 (UniProtKB | ENZYME | Rhea)
  • prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin F2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin F2alpha + NADP+ = prostaglandin E2 + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.1.1.189 (UniProtKB | ENZYME | Rhea)
  • a primary alcohol + NADP+ = an aldehyde + NADPH + H+
    EC:1.1.1.71 (UniProtKB | ENZYME | Rhea)
  • a secondary alcohol + NADP+ = a ketone + NADPH + H+
    EC:1.1.1.184 (UniProtKB | ENZYME | Rhea)
  • corticosterone + NADPH + H+ = 20beta-dihydrocorticosterone + NADP+
    This reaction proceeds in the forward direction.
  • cortisol + NADPH + H+ = 20beta-dihydrocortisol + NADP+
    This reaction proceeds in the forward direction.
  • daunorubicin + NADPH + H+ = 13-dihydrodaunorubicin + NADP+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbonyl reductase [NADPH] 1
  • EC number
  • Alternative names
    • 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
    • 20-beta-hydroxysteroid dehydrogenase
    • Alcohol dehydrogenase [NAD(P)+] CBR1
    • Prostaglandin 9-ketoreductase
    • Prostaglandin-E(2) 9-reductase

Organism names

Accessions

  • Primary accession
    A0A8C0T807

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    40,579
  • Last updated
    2022-01-19 v1
  • Checksum
    3BB90310CB29B61B
MSAASRVALVTGANKGIGFAIARELCRQFSGDVVLTARDEARGRAAVQQLQAEGLSPRFHLLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKTNDPTPFHIQAEVTMKTNFFGTRDVCTELLPLMKPQGRVVNVSSVVSVRALKSCSPELQQKFRSEAITEEELVGLMNKFVEDTKKGVHRNEGWPDNAYGVTKIGVTVLSRIHARKLSEQRRDDKILLNACCPGWVRTDMAGPRAPKSPEEGAETPVYLALLPSDAEGPHGEFLMEKKVEQWDLCRNFPGDMVLTVRDQTRGRGRAARQHLKAEGLSLHFHLLAIDNLQSIRTLRDFLWEEFGGLDVLVNNAGITFKCKNMGTLRTGDLR

Genome annotation databases

Similar Proteins

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