A0A8C0RTX1 · A0A8C0RTX1_CANLF

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site277
Active site335
Active site358
Binding site398Ca2+ (UniProtKB | ChEBI)
Binding site400Ca2+ (UniProtKB | ChEBI)
Binding site447Ca2+ (UniProtKB | ChEBI)
Binding site452Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytosol
Cellular Componentextracellular region
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular Functionpeptidase activity
Molecular Functionprotein-glutamine gamma-glutamyltransferase activity
Biological Processpeptide cross-linking
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-glutamine gamma-glutamyltransferase 2
  • EC number
  • Alternative names
    • Isopeptidase TGM2
    • Protein-glutamine deamidase TGM2
    • Protein-glutamine dopaminyltransferase TGM2
    • Protein-glutamine histaminyltransferase TGM2
    • Protein-glutamine noradrenalinyltransferase TGM2

Gene names

    • Name
      TGM2

Organism names

Accessions

  • Primary accession
    A0A8C0RTX1
  • Secondary accessions
    • A0A8P0P9X0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Monomer. Interacts with phospholipase C; promoting alpha-1 adrenergic receptor signaling. Interacts with PLCD1.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain269-361Transglutaminase-like
Region663-692Disordered

Sequence similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    692
  • Mass (Da)
    77,507
  • Last updated
    2022-01-19 v1
  • Checksum
    6FE51E9D3C51F151
MAEDLVLEKCDLELEANGRDHHTAGLCQGRLVVRRGQPFWLTLHFTGRSYESSVDSLTFSAVTGPDPSEEAGTKARFSLSSAVEEGAWTAVVMDQQDSVLSLQLSTPPNAPVGLYRLSLEASTGYQGSSFVLGHFTLLFNSWCPADAVYLDSDEERREYVLSQQGFIYQGSVKFIKSIPWNFGQFEDGILDICLMLLDRNPKFLKDACRDCSSRSNPIYVGRVVSAMVNCNDDQGVLLGRWDNNYKDGISPMFWIGSVDILRRWKTSGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNFNSAHDQNSNLLIEYVYNKFGEIQKEKSEMIWNYHCWVESWMSRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAAFVFAEVNADVVNWIQQDDGSLCKSTNNSQTVGMKISTKSVGRDEREDITHNYKYPEGSPEEREAFRKANHLNKLTEKEETGLAMRIRVSESMSMGSDFDVFAYINNNTSESHSCRLLLHARTVSYNGILGPECGTKDLLNLSLEPFSEKSIPLRILYEKYCECLTESNLIKVRGLLVEQAANNYLLAERDIYLENPEIKIRILGEPKQNRKLVAEASLRNPLTVPLLGCSFTMEGAGLTEEQKVMDVPDPVEAGEGGQAAASWKHMYPRARTGSAHTLSRPPHFSPPQAWADAQTHTPARV

Genome annotation databases

Similar Proteins

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