A0A8C0RTX1 · A0A8C0RTX1_CANLF
- ProteinProtein-glutamine gamma-glutamyltransferase 2
- GeneTGM2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids692 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- L-glutaminyl-[protein] + (R)-noradrenaline = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
- L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
- L-glutaminyl-[protein] + dopamine = 5-dopaminyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
- L-glutaminyl-[protein] + histamine = 5-histaminyl-L-glutamyl-[protein] + NH4+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 277 | ||||
Active site | 335 | ||||
Active site | 358 | ||||
Binding site | 398 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 400 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 447 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 452 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytosol | |
Cellular Component | extracellular region | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | metal ion binding | |
Molecular Function | peptidase activity | |
Molecular Function | protein-glutamine gamma-glutamyltransferase activity | |
Biological Process | peptide cross-linking | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein-glutamine gamma-glutamyltransferase 2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8C0RTX1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Monomer. Interacts with phospholipase C; promoting alpha-1 adrenergic receptor signaling. Interacts with PLCD1.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 269-361 | Transglutaminase-like | |||
Region | 663-692 | Disordered | |||
Sequence similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length692
- Mass (Da)77,507
- Last updated2022-01-19 v1
- Checksum6FE51E9D3C51F151