A0A8C0PRA4 · A0A8C0PRA4_CANLF
- ProteinTriacylglycerol lipase
- GenePNLIPRP2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids470 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H+This reaction proceeds in the forward direction.
- 1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H+This reaction proceeds in the forward direction.
- 1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H+This reaction proceeds in the forward direction.
- a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+This reaction proceeds in the forward direction.
- 1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H+This reaction proceeds in the forward direction.
- 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H+This reaction proceeds in the forward direction.
- 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H+This reaction proceeds in the forward direction.
- 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H+This reaction proceeds in the forward direction.
- 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H+This reaction proceeds in the forward direction.
- long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+This reaction proceeds in the forward direction.
- long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H+This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H+This reaction proceeds in the forward direction.
- di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Glycolipid metabolism.
Lipid metabolism.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 172 | Nucleophile | |||
Active site | 196 | Charge relay system | |||
Binding site | 207 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 210 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 212 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 215 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 283 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | neuron projection | |
Cellular Component | zymogen granule membrane | |
Molecular Function | metal ion binding | |
Molecular Function | triacylglycerol lipase activity | |
Biological Process | lipid catabolic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTriacylglycerol lipase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8C0PRA4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Zymogen granule membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-18 | ||||
Chain | PRO_5042658533 | 19-470 | Triacylglycerol lipase | ||
Disulfide bond | 22↔28 | ||||
Disulfide bond | 110↔121 | ||||
Disulfide bond | 257↔281 | ||||
Disulfide bond | 305↔316 | ||||
Disulfide bond | 319↔324 | ||||
Disulfide bond | 454↔470 | ||||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length470
- Mass (Da)52,833
- Last updated2022-01-19 v1
- Checksum2E5D6FC9C9676F36