A0A8C0PRA4 · A0A8C0PRA4_CANLF

Function

Catalytic activity

  • (9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + octanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • 1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + dodecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoyl-3-beta-D-galactosyl-sn-glycerol + dodecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H+
    This reaction proceeds in the forward direction.
  • long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.26 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.3 (UniProtKB | ENZYME | Rhea)
  • di-(9Z)-octadecenoylglycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.

Pathway

Glycerolipid metabolism; triacylglycerol degradation.
Glycolipid metabolism.
Lipid metabolism.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site172Nucleophile
Active site196Charge relay system
Binding site207Ca2+ (UniProtKB | ChEBI)
Binding site210Ca2+ (UniProtKB | ChEBI)
Binding site212Ca2+ (UniProtKB | ChEBI)
Binding site215Ca2+ (UniProtKB | ChEBI)
Active site283Charge relay system

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentneuron projection
Cellular Componentzymogen granule membrane
Molecular Functionmetal ion binding
Molecular Functiontriacylglycerol lipase activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triacylglycerol lipase
  • EC number
  • Alternative names
    • Pancreatic lipase

Gene names

    • Name
      PNLIPRP2

Organism names

Accessions

  • Primary accession
    A0A8C0PRA4

Proteomes

Subcellular Location

Secreted
Zymogen granule membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_504265853319-470Triacylglycerol lipase
Disulfide bond22↔28
Disulfide bond110↔121
Disulfide bond257↔281
Disulfide bond305↔316
Disulfide bond319↔324
Disulfide bond454↔470

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain358-470PLAT

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    470
  • Mass (Da)
    52,833
  • Last updated
    2022-01-19 v1
  • Checksum
    2E5D6FC9C9676F36
MLPSWTVGLLLLATVVRGKEICYGHLGCFPDDKPWSGTLQRPFKLFPWNPKDINTRFLLYTNENPNNFQLITATDLDTIEASNFQLDRKTRFIIHGFIDKGEENWLSDMCKKMFKVEKVNCICVDWKRGAKTRYSQAIQNIRVVGAQIAFFIQQLSTELGYRPEDAHLIGHSLGAHAAAEAGRRLGGRVGRITGLDPAQPCFQGTPEEVRLDPSDAMFVDVIHTDCAPIIPFLGFGMSQKVGHLDFYPNGGKQMPGCQKNALSTIIDINGIWEGARDFVACNHLRSYKYYSSSILSPDGFLGYPCASYHEFQEDSCFPCPAEGCPQMGHYADRFQRNTSAVGQTFFLNTGDSGNFTCWRYRVSVTLAGKKKTSGYFRIALYGSNANSKQYEIFKGSLQPHAIHMRNIDVDLNVGKIQKVKFLWNNHVINLFRPKLGASQITVQSGENGTKYNFCSSDMVREDVLQSLYPC

Genome annotation databases

Similar Proteins

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