A0A8C0N7E5 · CLD4_CANLF

Function

function

Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity).
May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity).
May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own (By similarity).

Caution

The intrinsic role of CLDN4 is debated. A function as an inter-claudin regulator has recently been postulated and may well explain both channel-forming and barrier properties inferred by knockout studies.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentbicellular tight junction
Cellular Componentchloride channel complex
Cellular Componentplasma membrane
Molecular Functionchloride channel activity
Molecular Functionstructural molecule activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Claudin-4

Gene names

    • Name
      CLDN4

Organism names

Accessions

  • Primary accession
    A0A8C0N7E5
  • Secondary accessions
    • A0A8P0NEI2

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Cytoplasmic
Transmembrane8-28Helical
Topological domain29-81Extracellular
Transmembrane82-102Helical
Topological domain103-117Cytoplasmic
Transmembrane118-138Helical
Topological domain139-160Extracellular
Transmembrane161-181Helical
Topological domain182-210Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004606711-210Claudin-4
Disulfide bond54↔64
Modified residue209Phosphotyrosine

Post-translational modification

Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.

Keywords

Interaction

Subunit

Can form heteropolymeric strands with other claudins (By similarity).
Interacts with CLDN8 (By similarity).
Interacts with CLDN1. Directly interacts with TJP1/ZO-1 (By similarity).
Interacts with TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (By similarity).

Structure

3D structure databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-103Interaction with EPHA2
Region209-210Interactions with TJP1, TJP2 and TJP3

Sequence similarities

Belongs to the claudin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    210
  • Mass (Da)
    22,091
  • Last updated
    2022-01-19 v1
  • Checksum
    9265548B39BE9FE8
MASMGLQVMGIALAVLGWLGAILSCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALMVVSIILAALGVLLSVVGGKCTNCVEDESAKAKTMIVAGVVFLLAGLLVMVPASWTANNIIRDFYNPLVVSGQKREMGASLYVGWAASGLLLLGGALLCCNCPPRADKPYSAKYSAAARSAPASNYV

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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