A0A8C0N7E5 · CLD4_CANLF
- ProteinClaudin-4
- GeneCLDN4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids210 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity).
May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity).
May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own (By similarity).
May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity).
May integrate into CLDN3 strands to modulate localized tight junction barrier properties. May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance. Cannot form tight junction strands on its own (By similarity).
Catalytic activity
- chloride(in) = chloride(out)
- bromide(in) = bromide(out)
- iodide(out) = iodide(in)
- fluoride(in) = fluoride(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | bicellular tight junction | |
Cellular Component | chloride channel complex | |
Cellular Component | plasma membrane | |
Molecular Function | chloride channel activity | |
Molecular Function | structural molecule activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameClaudin-4
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8C0N7E5
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-7 | Cytoplasmic | ||||
Sequence: MASMGLQ | ||||||
Transmembrane | 8-28 | Helical | ||||
Sequence: VMGIALAVLGWLGAILSCALP | ||||||
Topological domain | 29-81 | Extracellular | ||||
Sequence: MWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAAR | ||||||
Transmembrane | 82-102 | Helical | ||||
Sequence: ALMVVSIILAALGVLLSVVGG | ||||||
Topological domain | 103-117 | Cytoplasmic | ||||
Sequence: KCTNCVEDESAKAKT | ||||||
Transmembrane | 118-138 | Helical | ||||
Sequence: MIVAGVVFLLAGLLVMVPASW | ||||||
Topological domain | 139-160 | Extracellular | ||||
Sequence: TANNIIRDFYNPLVVSGQKREM | ||||||
Transmembrane | 161-181 | Helical | ||||
Sequence: GASLYVGWAASGLLLLGGALL | ||||||
Topological domain | 182-210 | Cytoplasmic | ||||
Sequence: CCNCPPRADKPYSAKYSAAARSAPASNYV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460671 | 1-210 | Claudin-4 | |||
Sequence: MASMGLQVMGIALAVLGWLGAILSCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALMVVSIILAALGVLLSVVGGKCTNCVEDESAKAKTMIVAGVVFLLAGLLVMVPASWTANNIIRDFYNPLVVSGQKREMGASLYVGWAASGLLLLGGALLCCNCPPRADKPYSAKYSAAARSAPASNYV | ||||||
Disulfide bond | 54↔64 | |||||
Sequence: CVVQSTGQMQC | ||||||
Modified residue | 209 | Phosphotyrosine | ||||
Sequence: Y |
Post-translational modification
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Keywords
- PTM
Interaction
Subunit
Can form heteropolymeric strands with other claudins (By similarity).
Interacts with CLDN8 (By similarity).
Interacts with CLDN1. Directly interacts with TJP1/ZO-1 (By similarity).
Interacts with TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (By similarity).
Interacts with CLDN8 (By similarity).
Interacts with CLDN1. Directly interacts with TJP1/ZO-1 (By similarity).
Interacts with TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
Interacts with EPHA2; phosphorylates CLDN4 and may regulate tight junctions (By similarity).
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-103 | Interaction with EPHA2 | ||||
Sequence: MASMGLQVMGIALAVLGWLGAILSCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALMVVSIILAALGVLLSVVGGK | ||||||
Region | 209-210 | Interactions with TJP1, TJP2 and TJP3 | ||||
Sequence: YV |
Sequence similarities
Belongs to the claudin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length210
- Mass (Da)22,091
- Last updated2022-01-19 v1
- Checksum9265548B39BE9FE8
Keywords
- Technical term