A0A8C0KQX3 · A0A8C0KQX3_CANLU

  • Protein
    Delta(14)-sterol reductase TM7SF2
  • Gene
    TM7SF2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase TM7SF2
  • EC number
  • Short names
    Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Sterol C14-reductase
    • Transmembrane 7 superfamily member 2

Gene names

    • Name
      TM7SF2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis

Accessions

  • Primary accession
    A0A8C0KQX3

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane17-37Helical
Transmembrane58-79Helical
Transmembrane156-174Helical
Transmembrane189-208Helical
Transmembrane220-239Helical
Transmembrane290-314Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    40,065
  • Last updated
    2022-01-19 v1
  • Checksum
    E0009BC9933EA078
MASPQGSRAPLEFGGPLGAAALMLLLPATMFHLLLVVRSGPARLLGPPPYLPGLQVLWSPRMLLLWLTWLGLQAALYLLPARKVAEGQELKDKSRLLYPINGNPIYDFFLGRELNPRVWSFDFKYFCELRPGLIGWVLINLAMLMQEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDLAWVPFTYSLQAQFLLHHPQPLGLPVASVICLINAVGYYIFRGANSQKNTFRKNPSDPRVADLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDEQQCLQKYGLAWHEYCRRVPYRILPYIY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C0KMP6A0A8C0KMP6_CANLUTM7SF2418

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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