A0A8C0KQX3 · A0A8C0KQX3_CANLU
- ProteinDelta(14)-sterol reductase TM7SF2
- GeneTM7SF2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids353 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H+ + NADPH
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + H+ + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + H+ + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase TM7SF2
- EC number
- Short namesDelta-14-SR
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8C0KQX3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 17-37 | Helical | ||||
Sequence: LGAAALMLLLPATMFHLLLVV | ||||||
Transmembrane | 58-79 | Helical | ||||
Sequence: WSPRMLLLWLTWLGLQAALYLL | ||||||
Transmembrane | 156-174 | Helical | ||||
Sequence: LAMWLVNGFQLLYVGDALW | ||||||
Transmembrane | 189-208 | Helical | ||||
Sequence: GFGFMLAFGDLAWVPFTYSL | ||||||
Transmembrane | 220-239 | Helical | ||||
Sequence: LGLPVASVICLINAVGYYIF | ||||||
Transmembrane | 290-314 | Helical | ||||
Sequence: LIMALAWSLPCGVSHLLPYFYLLYF |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)40,065
- Last updated2022-01-19 v1
- ChecksumE0009BC9933EA078
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C0KMP6 | A0A8C0KMP6_CANLU | TM7SF2 | 418 |
Keywords
- Technical term