A0A8C0BWS2 · A0A8C0BWS2_9AVES
- ProteinPeroxisomal bifunctional enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids703 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoAThis reaction proceeds in the forward direction.
- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3E)-decenoyl-CoA = (2E)-decenoyl-CoAThis reaction proceeds in the forward direction.
- (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
- (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoAThis reaction proceeds in the backward direction.
- (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoAThis reaction proceeds in the backward direction.
- (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + H+ + NADHThis reaction proceeds in the forward direction.
- (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2OThis reaction proceeds in the backward direction.
- (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | peroxisome | |
Molecular Function | NAD+ binding | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal bifunctional enzyme
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Accipitriformes > Accipitridae > Accipitrinae > Buteo
Accessions
- Primary accessionA0A8C0BWS2
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 280-455 | 3-hydroxyacyl-CoA dehydrogenase NAD binding | ||||
Sequence: LGLGTMGRGIVTSLVKANIPVVALEQDLEYLNMGRKAVMLLLEREAMKMEQGAQTLDFHNPARLHFTVDFDLLCDVDLVIEAVFENMALKKEIFHKLSRICKPGAFLCTNTSALNIDEIASATSRPQQVIGTHFFSPAHVMRLLEIIYGHHTSPTTIATAMQLAKVLKKVGVVVGN | ||||||
Domain | 458-562 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: GFVGNRMMFPYVQQAVFLLEEGSRPEAVDQVLEDFGFKIGPFRMSDLAGLDVGWRSRKGQGLTGASLPPGTPARQRHGHRYSPLPDLLCENGRFGQKTGKGWYQY | ||||||
Domain | 599-688 | 3-hydroxyacyl-CoA dehydrogenase C-terminal | ||||
Sequence: ILERCLFSLINEGFNILAEGIASGPEHLDVIYINGYGWPKHRGGPMFYASTIGLPRVLAKLQKYSKAHPDVPGLQPSVFLKKLVAMGNPP |
Sequence similarities
Belongs to the enoyl-CoA hydratase/isomerase family.
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length703
- Mass (Da)76,944
- Last updated2022-01-19 v1
- ChecksumCA2D67ACC48E22E0
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C0HR15 | A0A8C0HR15_9AVES | 717 | |||
A0A8C0HQL0 | A0A8C0HQL0_9AVES | 711 | |||
A0A8C0BUE6 | A0A8C0BUE6_9AVES | 695 |
Keywords
- Technical term