A0A8C0BWS2 · A0A8C0BWS2_9AVES

  • Protein
    Peroxisomal bifunctional enzyme
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

  • (2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA
    This reaction proceeds in the forward direction.
  • (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3E)-decenoyl-CoA = (2E)-decenoyl-CoA
    This reaction proceeds in the forward direction.
  • (3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA
    This reaction proceeds in the forward direction.
  • (3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA
    This reaction proceeds in the backward direction.
  • (3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA
    This reaction proceeds in the backward direction.
  • (3S)-hydroxydecanoyl-CoA + NAD+ = 3-oxodecanoyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
  • (3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3S)-hydroxyhexadecanedioyl-CoA + NAD+ = 3-oxohexadecanedioyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
  • (3S)-hydroxyhexadecanoyl-CoA + NAD+ = 3-oxohexadecanoyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
  • (3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O
    This reaction proceeds in the backward direction.
  • (3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA
    This reaction proceeds in the forward direction.
  • a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
    This reaction proceeds in the forward direction.
    EC:5.3.3.8 (UniProtKB | ENZYME | Rhea)
  • a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + H+ + NADH
    This reaction proceeds in the forward direction.
    EC:1.1.1.35 (UniProtKB | ENZYME | Rhea)
  • a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA
    This reaction proceeds in the forward direction.
    EC:5.3.3.8 (UniProtKB | ENZYME | Rhea)
  • a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O
    This reaction proceeds in the forward direction.
    EC:4.2.1.17 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; fatty acid beta-oxidation.

GO annotations

AspectTerm
Cellular Componentperoxisome
Molecular FunctionNAD+ binding
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisomal bifunctional enzyme
  • EC number
  • Alternative names
    • Multifunctional enzyme 1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Accipitriformes > Accipitridae > Accipitrinae > Buteo

Accessions

  • Primary accession
    A0A8C0BWS2

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain280-4553-hydroxyacyl-CoA dehydrogenase NAD binding
Domain458-5623-hydroxyacyl-CoA dehydrogenase C-terminal
Domain599-6883-hydroxyacyl-CoA dehydrogenase C-terminal

Sequence similarities

Belongs to the enoyl-CoA hydratase/isomerase family.
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    703
  • Mass (Da)
    76,944
  • Last updated
    2022-01-19 v1
  • Checksum
    CA2D67ACC48E22E0
LEDGLKTADADPSVKAVMICGENGKFSAGADIRGFSSLKRRGIALGPIISLIERSEKPVVAAIEGIALGGGLEVALGCHYRIAHVKARMGFPEVTIGLLPGAEGTQRLPRLIGVPAALDIITTGRHIPATEALKLGLVDEVVEENTVEAAICLANKVIESEQSQPLGLRRLSLKPVPELPNMEAFLSEALVKVKKQGHGCLAPELCFQAVKAATEQPFAVGVQKERELFNILLTSGQAQALQYAFFAERAVQKWTTPSGASWKTASPQPMFSDSVSLLSLGLGTMGRGIVTSLVKANIPVVALEQDLEYLNMGRKAVMLLLEREAMKMEQGAQTLDFHNPARLHFTVDFDLLCDVDLVIEAVFENMALKKEIFHKLSRICKPGAFLCTNTSALNIDEIASATSRPQQVIGTHFFSPAHVMRLLEIIYGHHTSPTTIATAMQLAKVLKKVGVVVGNCFGFVGNRMMFPYVQQAVFLLEEGSRPEAVDQVLEDFGFKIGPFRMSDLAGLDVGWRSRKGQGLTGASLPPGTPARQRHGHRYSPLPDLLCENGRFGQKTGKGWYQYEKAGGRTAKPDPWLHNFLSQYRDTHHINTRFVDQEEILERCLFSLINEGFNILAEGIASGPEHLDVIYINGYGWPKHRGGPMFYASTIGLPRVLAKLQKYSKAHPDVPGLQPSVFLKKLVAMGNPPLKEWMSYLSRQSNKL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C0HR15A0A8C0HR15_9AVES717
A0A8C0HQL0A0A8C0HQL0_9AVES711
A0A8C0BUE6A0A8C0BUE6_9AVES695

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp