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A0A8C0AI28 · A0A8C0AI28_BOSMU

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentnucleus
Cellular Componentpericentric heterochromatin
Molecular FunctionATP binding
Molecular FunctionATP-dependent chromatin remodeler activity
Molecular Functionchromatin DNA binding
Molecular Functionhydrolase activity
Molecular Functionmetal ion binding
Molecular Functionmethylated histone binding
Biological ProcessDNA repair
Biological Processregulation of macromolecule metabolic process
Biological Processreplication fork processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulator ATRX
  • EC number
  • Alternative names
    • ATP-dependent helicase ATRX
    • X-linked nuclear protein

Gene names

    • Name
      ATRX

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A8C0AI28

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Interacts with DAXX to form the chromatin remodeling complex ATRX:DAXX. Probably binds EZH2. Binds annexin V in a calcium and phosphatidylcholine/phosphatidylserine-dependent manner. Interacts directly with CBX5 via the PxVxL motif. Interacts with RAD50, MRE11 and NBN; indicative for an association with the MRN complex. Interacts with histone MACROH2A1. Interacts with histone H3 peptides methylated at 'Lys-10' with preferences H3K9me3 > H3K9me2 > H3K9me1. Interacts with histone H3 peptides unmethylated at 'Lys-5' (H3K4me0). Interacts with MECP2, SMC1 and SMC3. Interacts with SETDB1, TRIM28 and ZNF274.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region17-88Disordered
Compositional bias27-52Polar residues
Compositional bias53-76Basic and acidic residues
Domain92-229PHD-type
Region391-444Disordered
Compositional bias410-439Basic and acidic residues
Region470-489Disordered
Region529-883Disordered
Compositional bias559-590Basic and acidic residues
Compositional bias594-609Polar residues
Compositional bias610-637Basic and acidic residues
Compositional bias650-665Basic and acidic residues
Compositional bias672-696Polar residues
Compositional bias711-728Basic and acidic residues
Compositional bias741-761Basic and acidic residues
Compositional bias768-792Basic and acidic residues
Compositional bias801-842Basic and acidic residues
Compositional bias853-879Basic and acidic residues
Compositional bias899-960Basic and acidic residues
Region899-1382Disordered
Compositional bias970-1055Basic and acidic residues
Compositional bias1088-1105Basic and acidic residues
Compositional bias1106-1122Polar residues
Compositional bias1123-1137Basic and acidic residues
Compositional bias1138-1163Polar residues
Compositional bias1179-1246Basic and acidic residues
Compositional bias1254-1273Basic and acidic residues
Compositional bias1305-1330Basic and acidic residues
Compositional bias1339-1353Basic and acidic residues
Compositional bias1354-1371Acidic residues
Domain1484-1671Helicase ATP-binding
Region1818-1904Disordered
Compositional bias1845-1859Polar residues
Compositional bias1873-1902Polar residues
Domain1923-2101Helicase C-terminal
Region2323-2353Disordered
Compositional bias2331-2345Pro residues

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,353
  • Mass (Da)
    267,405
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    135B2F958A6828782CF0E8BE23FFFC0B
MSESKLNTLVQKLHDFLAHSSEESEETSSPPRLVMNQSTDKASGSGNNSDMMENSREEVRITWKSDDEKTLDETVNEDASNENSENDITMQSLPKDGLHGIVSCTACGQQVNHFQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKVDNEKTSKVYEHAPRFSPKKNSSNCNGEEKKLDDSYSGSVTYSYSALIVPKDMIKKAKKLIETTANMNSSYVKFLKQATDNSEINSATKLRQLKAFKSVLADIKKAHLALEEDLNSEIQALDAVNKEKNTKEHKVIDAKSETKVRKGEKPCVLERKDISKSEGKLSRKQVDSEHIGQSVAVEEQRAHKNDSTEHKKSDKKEPQYEPSNTAEDLDMDIVSVPSSVPEDIFENLETAMEVQSSAEYQGDGNSGTEQELETSVKLNITSKDNRGGIKSKTTAKVTKELYVKLTPVSLSISPIKGADCQEVPQDKDSYKSSCLNPKPENCELGQEKNDNEHLAKSEVPLLSEESDLRRSPRVKTTPLRRQTETNRTTSNSDEENNETVKEQQKLSVPMRKKDKRNSSDSAIDNPKPNKLPKSKQSEIVDHISDSDEMLTILKDMPSMSHSSSDTDINEPHTNNKKTFYSEIQRGKDDKRKRKRKSSTSGSDFDIKKGKSVKKAIISKKKRQNQSESSNYDSELEKEIKRMSKIGTARTTKKRVPNKEYYDSSEDEKHSKQGMDNQGHKSLRTAQEGPSDDVERKQERENFSSAEGTVDKDKTIMELRDRLSKKQQPNVSSESADKLCSGKEESFNSPEDKKVAESKGKSKHQRTRMCQKILGGLCDVAEKFSEKEQSDESSEDDNEQSKKEIEEKEKKTADLNKKVMEQEYESSSDTTEKLPEGEEICDFPKSIKQNKSSKGELSDNSEKLPGKRESCDSSEDKRSKNGTSSREKKRFNLPEKSSRKRQDCSSSDTEKYSMKEDDCDFSDKRPKGIELRERRNLNSNRNSKEVQSGSSSDVEESSEDNKNLKKQRALAKKKAGSIKEKMRNSLRTSTKRKQADITSSSSSDIGDDDQKSVGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDESEEGKKRTGKHNEENPGDEEIKNQAISESDSDSEESKKPRYRHRLLRHKLTLSDGESGEEKKMKPKEHKEAKSRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEDKEEDEEEDEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTPIQCKLYQYYLDHLTGVGNSSEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKAKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILECLVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMYQSVAGGMQPPPLQRAPPPMRSKNPGPSPGKSM

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8B9YJG6A0A8B9YJG6_BOSMUATRX2395
A0A8C0AHY6A0A8C0AHY6_BOSMUATRX2392
A0A8B9YNX0A0A8B9YNX0_BOSMUATRX2386
A0A8B9YJ17A0A8B9YJ17_BOSMUATRX2383
A0A8B9YIK0A0A8B9YIK0_BOSMUATRX1682
A0A8B9YGM0A0A8B9YGM0_BOSMUATRX2334
A0A8B9YHH9A0A8B9YHH9_BOSMUATRX2380

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias27-52Polar residues
Compositional bias53-76Basic and acidic residues
Compositional bias410-439Basic and acidic residues
Compositional bias559-590Basic and acidic residues
Compositional bias594-609Polar residues
Compositional bias610-637Basic and acidic residues
Compositional bias650-665Basic and acidic residues
Compositional bias672-696Polar residues
Compositional bias711-728Basic and acidic residues
Compositional bias741-761Basic and acidic residues
Compositional bias768-792Basic and acidic residues
Compositional bias801-842Basic and acidic residues
Compositional bias853-879Basic and acidic residues
Compositional bias899-960Basic and acidic residues
Compositional bias970-1055Basic and acidic residues
Compositional bias1088-1105Basic and acidic residues
Compositional bias1106-1122Polar residues
Compositional bias1123-1137Basic and acidic residues
Compositional bias1138-1163Polar residues
Compositional bias1179-1246Basic and acidic residues
Compositional bias1254-1273Basic and acidic residues
Compositional bias1305-1330Basic and acidic residues
Compositional bias1339-1353Basic and acidic residues
Compositional bias1354-1371Acidic residues
Compositional bias1845-1859Polar residues
Compositional bias1873-1902Polar residues
Compositional bias2331-2345Pro residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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