A0A8C0AI28 · A0A8C0AI28_BOSMU
- ProteinTranscriptional regulator ATRX
- GeneATRX
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2353 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | nucleus | |
Cellular Component | pericentric heterochromatin | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent chromatin remodeler activity | |
Molecular Function | chromatin DNA binding | |
Molecular Function | hydrolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | methylated histone binding | |
Biological Process | DNA repair | |
Biological Process | regulation of macromolecule metabolic process | |
Biological Process | replication fork processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscriptional regulator ATRX
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A8C0AI28
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts with DAXX to form the chromatin remodeling complex ATRX:DAXX. Probably binds EZH2. Binds annexin V in a calcium and phosphatidylcholine/phosphatidylserine-dependent manner. Interacts directly with CBX5 via the PxVxL motif. Interacts with RAD50, MRE11 and NBN; indicative for an association with the MRN complex. Interacts with histone MACROH2A1. Interacts with histone H3 peptides methylated at 'Lys-10' with preferences H3K9me3 > H3K9me2 > H3K9me1. Interacts with histone H3 peptides unmethylated at 'Lys-5' (H3K4me0). Interacts with MECP2, SMC1 and SMC3. Interacts with SETDB1, TRIM28 and ZNF274.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 17-88 | Disordered | |||
Compositional bias | 27-52 | Polar residues | |||
Compositional bias | 53-76 | Basic and acidic residues | |||
Domain | 92-229 | PHD-type | |||
Region | 391-444 | Disordered | |||
Compositional bias | 410-439 | Basic and acidic residues | |||
Region | 470-489 | Disordered | |||
Region | 529-883 | Disordered | |||
Compositional bias | 559-590 | Basic and acidic residues | |||
Compositional bias | 594-609 | Polar residues | |||
Compositional bias | 610-637 | Basic and acidic residues | |||
Compositional bias | 650-665 | Basic and acidic residues | |||
Compositional bias | 672-696 | Polar residues | |||
Compositional bias | 711-728 | Basic and acidic residues | |||
Compositional bias | 741-761 | Basic and acidic residues | |||
Compositional bias | 768-792 | Basic and acidic residues | |||
Compositional bias | 801-842 | Basic and acidic residues | |||
Compositional bias | 853-879 | Basic and acidic residues | |||
Compositional bias | 899-960 | Basic and acidic residues | |||
Region | 899-1382 | Disordered | |||
Compositional bias | 970-1055 | Basic and acidic residues | |||
Compositional bias | 1088-1105 | Basic and acidic residues | |||
Compositional bias | 1106-1122 | Polar residues | |||
Compositional bias | 1123-1137 | Basic and acidic residues | |||
Compositional bias | 1138-1163 | Polar residues | |||
Compositional bias | 1179-1246 | Basic and acidic residues | |||
Compositional bias | 1254-1273 | Basic and acidic residues | |||
Compositional bias | 1305-1330 | Basic and acidic residues | |||
Compositional bias | 1339-1353 | Basic and acidic residues | |||
Compositional bias | 1354-1371 | Acidic residues | |||
Domain | 1484-1671 | Helicase ATP-binding | |||
Region | 1818-1904 | Disordered | |||
Compositional bias | 1845-1859 | Polar residues | |||
Compositional bias | 1873-1902 | Polar residues | |||
Domain | 1923-2101 | Helicase C-terminal | |||
Region | 2323-2353 | Disordered | |||
Compositional bias | 2331-2345 | Pro residues | |||
Sequence similarities
Belongs to the SNF2/RAD54 helicase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,353
- Mass (Da)267,405
- Last updated2022-01-19 v1
- MD5 Checksum135B2F958A6828782CF0E8BE23FFFC0B
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8B9YJG6 | A0A8B9YJG6_BOSMU | ATRX | 2395 | ||
A0A8C0AHY6 | A0A8C0AHY6_BOSMU | ATRX | 2392 | ||
A0A8B9YNX0 | A0A8B9YNX0_BOSMU | ATRX | 2386 | ||
A0A8B9YJ17 | A0A8B9YJ17_BOSMU | ATRX | 2383 | ||
A0A8B9YIK0 | A0A8B9YIK0_BOSMU | ATRX | 1682 | ||
A0A8B9YGM0 | A0A8B9YGM0_BOSMU | ATRX | 2334 | ||
A0A8B9YHH9 | A0A8B9YHH9_BOSMU | ATRX | 2380 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 27-52 | Polar residues | |||
Compositional bias | 53-76 | Basic and acidic residues | |||
Compositional bias | 410-439 | Basic and acidic residues | |||
Compositional bias | 559-590 | Basic and acidic residues | |||
Compositional bias | 594-609 | Polar residues | |||
Compositional bias | 610-637 | Basic and acidic residues | |||
Compositional bias | 650-665 | Basic and acidic residues | |||
Compositional bias | 672-696 | Polar residues | |||
Compositional bias | 711-728 | Basic and acidic residues | |||
Compositional bias | 741-761 | Basic and acidic residues | |||
Compositional bias | 768-792 | Basic and acidic residues | |||
Compositional bias | 801-842 | Basic and acidic residues | |||
Compositional bias | 853-879 | Basic and acidic residues | |||
Compositional bias | 899-960 | Basic and acidic residues | |||
Compositional bias | 970-1055 | Basic and acidic residues | |||
Compositional bias | 1088-1105 | Basic and acidic residues | |||
Compositional bias | 1106-1122 | Polar residues | |||
Compositional bias | 1123-1137 | Basic and acidic residues | |||
Compositional bias | 1138-1163 | Polar residues | |||
Compositional bias | 1179-1246 | Basic and acidic residues | |||
Compositional bias | 1254-1273 | Basic and acidic residues | |||
Compositional bias | 1305-1330 | Basic and acidic residues | |||
Compositional bias | 1339-1353 | Basic and acidic residues | |||
Compositional bias | 1354-1371 | Acidic residues | |||
Compositional bias | 1845-1859 | Polar residues | |||
Compositional bias | 1873-1902 | Polar residues | |||
Compositional bias | 2331-2345 | Pro residues | |||
Keywords
- Technical term