A0A8B9XJK6 · A0A8B9XJK6_BOSMU
- ProteinAmine oxidase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids932 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
Catalytic activity
- (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
- (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4+
- 2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4+
- serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4+
- tryptamine + O2 + H2O = indole-3-acetaldehyde + H2O2 + NH4+
- tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4+
- kynuramine + O2 + H2O = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4+This reaction proceeds in the forward direction.
- dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | primary methylamine oxidase activity | |
Biological Process | catecholamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAmine oxidase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A8B9XJK6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-35 | Disordered | |||
Compositional bias | 123-188 | Polar residues | |||
Region | 123-287 | Disordered | |||
Compositional bias | 199-213 | Pro residues | |||
Compositional bias | 214-234 | Polar residues | |||
Compositional bias | 243-284 | Polar residues | |||
Compositional bias | 304-349 | Polar residues | |||
Region | 304-426 | Disordered | |||
Compositional bias | 357-371 | Pro residues | |||
Compositional bias | 409-426 | Polar residues | |||
Domain | 441-878 | Amine oxidase | |||
Sequence similarities
Belongs to the flavin monoamine oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length932
- Mass (Da)100,982
- Last updated2022-01-19 v1
- Checksum8A5D45C8BC507ADA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8B9XG10 | A0A8B9XG10_BOSMU | 895 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 123-188 | Polar residues | |||
Compositional bias | 199-213 | Pro residues | |||
Compositional bias | 214-234 | Polar residues | |||
Compositional bias | 243-284 | Polar residues | |||
Compositional bias | 304-349 | Polar residues | |||
Compositional bias | 357-371 | Pro residues | |||
Compositional bias | 409-426 | Polar residues | |||
Keywords
- Technical term