A0A8B9XJK6 · A0A8B9XJK6_BOSMU

Function

function

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentmitochondrial outer membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionprimary methylamine oxidase activity
Biological Processcatecholamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amine oxidase
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A8B9XJK6

Proteomes

Subcellular Location

Mitochondrion outer membrane
; Single-pass type IV membrane protein

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-35Disordered
Compositional bias123-188Polar residues
Region123-287Disordered
Compositional bias199-213Pro residues
Compositional bias214-234Polar residues
Compositional bias243-284Polar residues
Compositional bias304-349Polar residues
Region304-426Disordered
Compositional bias357-371Pro residues
Compositional bias409-426Polar residues
Domain441-878Amine oxidase

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    932
  • Mass (Da)
    100,982
  • Last updated
    2022-01-19 v1
  • Checksum
    8A5D45C8BC507ADA
MSAPNSAAPFSSGRRGGNERELQRSPGVGNLPAQIPEAANIAGVASSSSWNTSSEWLTSHQHSSRLSNTSTAADARYTRGFSAPSQLIPGFGLRTDTGLRVDIWGFGTRGLNDRVRMSALHPTTTDEAASASNPGPSSPRVSVQGSVQPSRSPRLPLHTTLHSAPGSTRISIGETPRPTNTFRGSVQGSISPVKPAFIKISAPAPPPPNNTPPVSLLGLTSPSVSGSPLGSVQGPPTPSNSPPLSGQESSRVSMSDFQQLSAKRSAPLSALSRESVQGSAPPSVVSFPESLARGSIAISDFSRVSIRGSSPPSDLSTPRSSIPGPLSPVNSQVSTQESTQLSEQSYPQRLVEGSAPPPDSPGVPVPGVAPPSAPGSAQESVEESAPPSGSPRDSVEKSAPPSARPTPVPTPRENRNQSMESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHVDYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKLRSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADRLAKVHKDIRKRKICELYAKVLGSQEALRPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAEDVPAVEITPSFWERNLPSVSGLLKIVGFSTSITAL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8B9XG10A0A8B9XG10_BOSMU895

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias123-188Polar residues
Compositional bias199-213Pro residues
Compositional bias214-234Polar residues
Compositional bias243-284Polar residues
Compositional bias304-349Polar residues
Compositional bias357-371Pro residues
Compositional bias409-426Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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