A0A8B9XCL9 · A0A8B9XCL9_BOSMU
- ProteinAlanine--glyoxylate aminotransferase 2, mitochondrial
- GeneAGXT2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids514 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Catalytic activity
- (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
- 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate
- 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate
- L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
- L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
- N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine
- N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
- N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate
- N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
- N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
- N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
- N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine
- N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
- oxaloacetate + L-alanine = L-aspartate + pyruvate
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | (R)-3-amino-2-methylpropionate-pyruvate transaminase activity | |
Molecular Function | alanine-glyoxylate transaminase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine biosynthetic process, by transamination of glyoxylate | |
Biological Process | glyoxylate catabolic process | |
Biological Process | L-alanine catabolic process, by transamination | |
Biological Process | positive regulation of nitric oxide biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlanine--glyoxylate aminotransferase 2, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A8B9XCL9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-27 | ||||
Chain | PRO_5034940155 | 28-514 | Alanine--glyoxylate aminotransferase 2, mitochondrial | ||
Interaction
Subunit
Homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length514
- Mass (Da)57,193
- Last updated2022-01-19 v1
- MD5 Checksum4721EF96BCB8BBCE2672627A4492A3B5
Keywords
- Technical term