A0A8B9W1R5 · A0A8B9W1R5_BOSMU

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1908100200300400500600700800900
Type
IDPosition(s)Description
Binding site186Zn2+ (UniProtKB | ChEBI); catalytic; in inhibited form
Binding site248Ca2+ 2 (UniProtKB | ChEBI)
Binding site248Ca2+ 1 (UniProtKB | ChEBI)
Binding site331Ca2+ 1 (UniProtKB | ChEBI)
Binding site331Ca2+ 2 (UniProtKB | ChEBI)
Binding site338Ca2+ 1 (UniProtKB | ChEBI)
Binding site388Zn2+ (UniProtKB | ChEBI); catalytic
Active site389
Binding site392Zn2+ (UniProtKB | ChEBI); catalytic
Binding site398Zn2+ (UniProtKB | ChEBI); catalytic
Binding site449Ca2+ 1 (UniProtKB | ChEBI)
Binding site452Ca2+ 2 (UniProtKB | ChEBI)
Binding site452Ca2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular region
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processextracellular matrix organization
Biological Processproteolysis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase with thrombospondin type 1 motif 5

Gene names

    • Name
      ADAMTS5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A8B9W1R5

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_503408410921-908
Disulfide bond320↔372
Disulfide bond349↔354
Disulfide bond366↔449
Disulfide bond404↔433
Disulfide bond475↔497
Glycosylation476N-linked (GlcNAc...) asparagine
Disulfide bond486↔507
Disulfide bond492↔526
Disulfide bond520↔531
Disulfide bond557↔594
Disulfide bond561↔599
Disulfide bond572↔584
Glycosylation706N-linked (GlcNAc...) asparagine

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region21-71Disordered
Region181-235Disordered
Compositional bias216-230Polar residues
Domain245-454Peptidase M12B

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    908
  • Mass (Da)
    99,147
  • Last updated
    2022-01-19 v1
  • Checksum
    59CB91AA15D4B550
MLLGWAALMLCALRLPPVAAGPTAAPAQDKAGQPRAAAVAAAAQPRGRRGEEAQEPAEPPGHPHPLAPQRGSRGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDSVGTAGLVPAGGGPNATRRHRGHCFYRGTVDGSPRSLARARYTLQPLLRGPWAESARILHVYTREGFSFEALPPRTSCETHASPPGARERPPAPSRPDGRWALAPQQLPGQSAPSSDGSQGPRTWWRRRRRSISRARQVELLLVADASMARMYGRGLQHYLLTLASIANKLYSHASIENHIRLVVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQIPGPEELPGQTYDASQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSVTPCPANGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPGDVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKVVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKSAPKANSVTSQGSNKVGSPTPQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCLLSQRPSAFKQCFQKKC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias216-230Polar residues

Keywords

Genome annotation databases

Similar Proteins

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