A0A8B9W1R5 · A0A8B9W1R5_BOSMU
- ProteinADAM metallopeptidase with thrombospondin type 1 motif 5
- GeneADAMTS5
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids908 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 186 | Zn2+ (UniProtKB | ChEBI); catalytic; in inhibited form | |||
Binding site | 248 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 248 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 331 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 331 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 338 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 388 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 389 | ||||
Binding site | 392 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 398 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 449 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 452 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 452 | Ca2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular region | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | extracellular matrix organization | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A8B9W1R5
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5034084109 | 21-908 | |||
Disulfide bond | 320↔372 | ||||
Disulfide bond | 349↔354 | ||||
Disulfide bond | 366↔449 | ||||
Disulfide bond | 404↔433 | ||||
Disulfide bond | 475↔497 | ||||
Glycosylation | 476 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 486↔507 | ||||
Disulfide bond | 492↔526 | ||||
Disulfide bond | 520↔531 | ||||
Disulfide bond | 557↔594 | ||||
Disulfide bond | 561↔599 | ||||
Disulfide bond | 572↔584 | ||||
Glycosylation | 706 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 21-71 | Disordered | |||
Region | 181-235 | Disordered | |||
Compositional bias | 216-230 | Polar residues | |||
Domain | 245-454 | Peptidase M12B | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length908
- Mass (Da)99,147
- Last updated2022-01-19 v1
- Checksum59CB91AA15D4B550
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 216-230 | Polar residues | |||
Keywords
- Technical term