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A0A8B9PWA4 · A0A8B9PWA4_APTOW

Function

Catalytic activity

Features

Showing features for binding site, active site.

1927100200300400500600700800900
Type
IDPosition(s)Description
Binding site459ATP (UniProtKB | ChEBI)
Active site556Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Cellular Componentpostsynapse
Cellular Componentpresynapse
Molecular FunctionATP binding
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionG protein-coupled receptor kinase activity
Biological Processdesensitization of G protein-coupled receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processprotein phosphorylation
Biological Processregulation of the force of heart contraction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-adrenergic receptor kinase 1
  • EC number

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Palaeognathae > Apterygiformes > Apterygidae > Apteryx

Accessions

  • Primary accession
    A0A8B9PWA4

Proteomes

Subcellular Location

Cell membrane
Cytoplasm
Postsynapse
Presynapse

Keywords

Interaction

Subunit

Interacts with the heterodimer formed by GNB1 and GNG2. Interacts with GIT1. Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1. Interacts with ADRB2.

Family & Domains

Features

Showing features for region, domain, coiled coil.

Type
IDPosition(s)Description
Region108-160Disordered
Domain293-414RGS
Domain430-692Protein kinase
Domain693-760AGC-kinase C-terminal
Domain797-891PH
Coiled coil879-906

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    927
  • Mass (Da)
    103,518
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    508F8D8D3609069FF9F87B9BFEF0D8BA
MRVDLMHTRTPPPAHATRFTTSLCTPGLHRRRRTGQRARTVVPITRTVRPAAKPGAHGAQATRVLRNARPGVHGGSATATRPAPASQCGHLRHAHVCLLHKHPRVPACRPAPPGGPGGSPGILPGSRCPSPATRPHFLPGAEAGHPCSQPPALSPPGLASLPGVREGPGCPELTAAPVRCAWLPRCSPACLGFPGGALLGLGCLGPLSLALPTWGTLRLSLTGAQQGVAGGAEGEAGVRGSLGTSVQAGWPGRGHGRCLEGGDGGGGRTEPVRRLPSIRSVMQKYLEDRGEVTFDKIFAQKIGYLLFRDFALNQAEEAKPLMEFYEEIKKYEKLDSEEERAARSRHIFDHYIMKELLACSHPFSKSATEHVQSHLSKKQVPPDLFQPYIEEICQNLRGGIFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAEMRFYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCMGRGAQEVKEEPFFKGLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLESDQELYRNFPLTISERWQQEVTETVFEAVNADTDKLEARKKAKNKQLGHEEDYAMGKDCIMHGYMAKLGNPFLTQWQRRYFYLFPNRLEWRGEGESPQSLLTMEEIDSVEETQVKERKCILLRIRGGKQFVLQCDSDPELAQWRKELRDAQRQAQQLLQRVPRMQNKPRSPVVELSKVPFIQRSANGL

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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