A0A8B9PWA4 · A0A8B9PWA4_APTOW
- ProteinBeta-adrenergic receptor kinase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids927 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- [beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 459 | ATP (UniProtKB | ChEBI) | |||
Active site | 556 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | postsynapse | |
Cellular Component | presynapse | |
Molecular Function | ATP binding | |
Molecular Function | G protein-coupled receptor binding | |
Molecular Function | G protein-coupled receptor kinase activity | |
Biological Process | desensitization of G protein-coupled receptor signaling pathway | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of the force of heart contraction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-adrenergic receptor kinase 1
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Palaeognathae > Apterygiformes > Apterygidae > Apteryx
Accessions
- Primary accessionA0A8B9PWA4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Interacts with the heterodimer formed by GNB1 and GNG2. Interacts with GIT1. Interacts with, and phosphorylates chemokine-stimulated CCR5. Interacts with ARRB1. Interacts with LPAR1 and LPAR2. Interacts with RALA in response to LPAR1 activation. ADRBK1 and RALA mutually inhibit each other's binding to LPAR1. Interacts with ADRB2.
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 108-160 | Disordered | |||
Domain | 293-414 | RGS | |||
Domain | 430-692 | Protein kinase | |||
Domain | 693-760 | AGC-kinase C-terminal | |||
Domain | 797-891 | PH | |||
Coiled coil | 879-906 | ||||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length927
- Mass (Da)103,518
- Last updated2022-01-19 v1
- MD5 Checksum508F8D8D3609069FF9F87B9BFEF0D8BA
Keywords
- Technical term