A0A8B8UY80 · A0A8B8UY80_SACPA
- ProteinCysteine proteinase 1, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids454 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.
Catalytic activity
- Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 73 | ||||
Active site | 369 | ||||
Active site | 392 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | cysteine-type aminopeptidase activity | |
Molecular Function | DNA binding | |
Biological Process | homocysteine catabolic process | |
Biological Process | proteolysis | |
Biological Process | response to toxic substance |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCysteine proteinase 1, mitochondrial
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionA0A8B8UY80
Organism-specific databases
Subcellular Location
Interaction
Subunit
Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
Structure
Sequence
- Sequence statusComplete
- Length454
- Mass (Da)51,998
- Last updated2022-01-19 v1
- MD5 ChecksumB6240E95116A97C2156923CEECDD20F5