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A0A8B8UY80 · A0A8B8UY80_SACPA

Function

function

Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

Catalytic activity

  • Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
    EC:3.4.22.40 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

145450100150200250300350400450
TypeIDPosition(s)Description
Active site73
Active site369
Active site392

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functioncysteine-type aminopeptidase activity
Molecular FunctionDNA binding
Biological Processhomocysteine catabolic process
Biological Processproteolysis
Biological Processresponse to toxic substance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine proteinase 1, mitochondrial
  • EC number

Gene names

    • ORF names
      SPAR_N00890

Organism names

Accessions

  • Primary accession
    A0A8B8UY80

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.

Family & Domains

Sequence similarities

Belongs to the peptidase C1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    51,998
  • Last updated
    2022-01-19 v1
  • MD5 Checksum
    B6240E95116A97C2156923CEECDD20F5
MSSSIDISKINSWNKEFQSDLTHQLATTVLKNYNADDALLNKTRLQKQDNRVFNTVVSTDSTPVTNQKSSGRCWLFAATNQLRLNVLSELNLKEFEISQAYLFFYDKLEKANYFLDQIVSSADQDVDSRLVQYLLAAPTEDGGQYSMFLNLVKKYGLIPKDLYGDLPYSTTASRKWNSLLTTKLREFAETLRTALKERSADDSKIVTLREQMQREIFRLMSLFMDIPPVQPNEQFTWEYVDKDKKIHTVKSTPLEFASKYAKLDASTPVSLINDPRHPYGKLIKIDRLGNVLGGDAVIYLNVDNETLSKLVVKRLQNNKAVFFGSHTPKFMDKKTGVMDIELWNYPAIGYNLSQQKASRIKYHESLMTHAMLITGCHVDETSKVPLRYRVENSWGKDSGKDGLYVMTQQYFEEYCFQIVVDINELPEELASKFTSGKEEPIVLPIWDPMGALAK

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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