A0A8B8UUE3 · A0A8B8UUE3_SACPA

Function

function

Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10-15ITP (UniProtKB | ChEBI)
Binding site45Mg2+ (UniProtKB | ChEBI)
Binding site58ITP (UniProtKB | ChEBI)
Binding site76Mg2+ (UniProtKB | ChEBI)
Binding site76-77ITP (UniProtKB | ChEBI)
Binding site151-154ITP (UniProtKB | ChEBI)
Binding site175ITP (UniProtKB | ChEBI)
Binding site180-181ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      HAM1
    • ORF names
      SPAR_J02510

Organism names

Accessions

  • Primary accession
    A0A8B8UUE3

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    22,011
  • Last updated
    2022-01-19 v1
  • Checksum
    83BD756B0D801939
MGNNEIVFVTGNANKLKEVQSILIQDVDSNNKTIHLINEALDLEELQDTDLNAIALAKGKQAVAVLGKGKPVFVEDTALRFDEFNGLPGAYIKWFLKSMGLDKIVKMLEPFENKNAEAVTTICFADSRGEYHFFQGITKGKIVPSRGPTTFGWDSIFEPFDSNGLTYAEMTKDAKNAISHRGKAFAQFKEYLYQNDF

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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