A0A8B7HA97 · S22AO_MICMU

Function

function

Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids, as well as bile acids, driven by an outward gradient of dicarboxylates such as glutarate or succinate (By similarity).
Transports androstanediol glucuronide (5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), estrone 3-sulfate, and estradiol-17-glucuronide (17beta-estradiol 17-O-(beta-D-glucuronate)), but not taurocholate (PubMed:31553721).

Catalytic activity

  • estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)
  • 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)
  • 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)
  • dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  • glutarate(in) + succinate(out) = glutarate(out) + succinate(in)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functiontransmembrane transporter activity
Biological Processlipid transport
Biological Processmonoatomic ion transport
Biological Processorganic anion transport
Biological Processsteroid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Steroid transmembrane transporter SLC22A24
  • Alternative names
    • Solute carrier family 22 member 24

Gene names

    • Name
      SLC22A24

Organism names

Accessions

  • Primary accession
    A0A8B7HA97

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-36Helical
Transmembrane146-166Helical
Transmembrane174-194Helical
Transmembrane204-224Helical
Transmembrane235-255Helical
Transmembrane260-280Helical
Transmembrane349-369Helical
Transmembrane380-400Helical
Transmembrane407-427Helical
Transmembrane436-456Helical
Transmembrane473-493Helical
Transmembrane495-515Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004566431-552Steroid transmembrane transporter SLC22A24

Structure

3D structure databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    552
  • Mass (Da)
    61,792
  • Last updated
    2022-01-19 v1
  • Checksum
    3A2CE0CEED2DE47E
MAFAVLLDQVGSLGRFQILQLAFLCIANILLFPHILLENFTAAVPGHRCWVHILDNDTVSHNDTGTLGQDALLRISIPLDSNLKPEKCRRFVHPQWQLLHLNRTFSNTSEPDTEPCVDGWVYEQSSFFSTVVTEWDLVCEWESQKSVVQSLFMAGSLLGSVIFGYLSDRFGRKMICSWCLLQLAISDTCAAFAPTFSVYCSLRFLAGSCVMTIMGHSFLLVIEWTNPQSRSMVTTLLLCASSVGQMLLGGLAFVIQDWRTLQLTVSIPIFVIFLSSRWLVESARWLITYNQLDKGLKELRRAARINGKKNAGEILTIEFLRSAMQEELDAARSQASIFCLFHAPRLRMIVLYLGFVRLAVSVPLYGLIFNLQYLGRNIYLFQVLFGAITATARFVALLVMNYMGRRISQVLFLLPVGLFILVNTFLDQEMQTLRTILATLGAGVLCIATTSGSVHFSELIPTVLRGTGGGINILFSRIGAALAPLLMIFVGFSPYLPWITYGVFPILAGLVVLLLPETKNLPLPNTIQDVENDRKETRKVKQEDNCMKVTQF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8C5YFW8A0A8C5YFW8_MICMUSLC22A24323

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABDC03005851
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
ABDC03005852
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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