A0A8B6X3K1 · A0A8B6X3K1_9BURK

Function

function

Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functiontransferase activity
Biological Processthiamine biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Thiamine pyrimidine synthase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Alcaligenaceae > Derxia

Accessions

  • Primary accession
    A0A8B6X3K1

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain45-258SsuA/THI5-like

Sequence similarities

Belongs to the NMT1/THI5 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    36,827
  • Last updated
    2022-01-19 v1
  • Checksum
    35457EECEA7624ED
MTSPSRRNFLRFSAAGLGALAAPAVIGQPSLTKIRFTLDFRVTGQVAPFFLALGKGYYREEGLEVSFDVGSGSVASITRVASGAYDMGFGDLNSLMEFTAQNNGVPQVQAVYQYYNRAPFAIIGRRDRGISDFKSLAGKNIAAAAVESTKRAWPIAARHLGMPANSLNWITTDFSARDNVVVRGDVDGATYFHDSALSLFQRMKPAELAVLPFADSGVVLYGNAVLAASKLVAENPKAVAGFVRATNRALLECLADPAPGVAFVKQREGLLDEATEVERFRITAQYIATAESRANGIGDVVAGNLQQQIDEVTEVFGLKLRPKADAVWNPAFLPAKAQRMARG

Keywords

Sequence databases

Similar Proteins

Disclaimer

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