A0A8B6NHY2 · A0A8B6NHY2_9PHAE

  • Protein
    Thiazole synthase
  • Gene
    thiG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for active site, binding site.

126920406080100120140160180200220240260
TypeIDPosition(s)Description
Active site107Schiff-base intermediate with DXP
Binding site1681-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site194-1951-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site216-2171-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchloroplast
Molecular Functionsulfurtransferase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiazole synthase
  • EC number

Gene names

    • Name
      thiG

Encoded on

  • Chloroplast

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SC
  • Taxonomic lineage
    Eukaryota > Sar > Stramenopiles > Ochrophyta > PX clade > Phaeophyceae > Fucales > Sargassaceae > Sargassum

Accessions

  • Primary accession
    A0A8B6NHY2

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer. Forms heterodimers with either ThiH or ThiS.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-259Thiazole synthase ThiG

Sequence similarities

Belongs to the ThiG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    269
  • Mass (Da)
    29,288
  • Last updated
    2021-09-29 v1
  • Checksum
    8925F8138EDFCB6A
MRKQDPLIIGNKSFNSRLIIGTGKYRNLHDMTSCLEKSGAEIVTVAIRRLNLSTVTTNNLIAKINWNKLWLLPNTAGAKTTEEAIRLAFLGRELSKRLGQQENNFIKLEVISDPKYLFPDPIGTLKAAEFLIKKGFSVLPYTNTDPMLAKHLEDIGCSTIMPLGSPIGSGQGIQNIENIKIIIENSKVPVIIDAGIGSSSEATYAMELGAEAVLINSAIAQAKNSIEMATAMNLAVRAGRKAYLAGQMIPQKFAQSSSPRKGLDFLKSE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT795189
EMBL· GenBank· DDBJ
QNU09455.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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