A0A8B5XYE9 · A0A8B5XYE9_9BACI

  • Protein
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • Gene
    metE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15-185-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site185-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1125-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1175-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site435-437L-homocysteine (UniProtKB | ChEBI)
Binding site435-437L-methionine (UniProtKB | ChEBI)
Binding site488L-homocysteine (UniProtKB | ChEBI)
Binding site488L-methionine (UniProtKB | ChEBI)
Binding site519-5205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5655-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site603L-homocysteine (UniProtKB | ChEBI)
Binding site603L-methionine (UniProtKB | ChEBI)
Binding site6095-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site645Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site645Zn2+ (UniProtKB | ChEBI); catalytic
Binding site647Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site647Zn2+ (UniProtKB | ChEBI); catalytic
Binding site669Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site669Zn2+ (UniProtKB | ChEBI); catalytic
Active site698Proton donor
Binding site730Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site730Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • ORF names
      FQP34_14445

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • GGC-P6A
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Peribacillus

Accessions

  • Primary accession
    A0A8B5XYE9

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-313Cobalamin-independent methionine synthase MetE N-terminal
Domain430-752Cobalamin-independent methionine synthase MetE C-terminal/archaeal

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    765
  • Mass (Da)
    86,700
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    E6B554280DBE08247E399A27772848A1
MKSSSLGYPRIGEDREWKRTLEAYWSGKIDEAEFTAQLKAIRLGNLQKQKKRGIDIIPVNDFTFYDQMLDMSVMFGLVPERYSAYEGGSVPLSVYYSMARGNNDEVASEMTKWFNTNYHYIVPELKLSQLTLTENKPLAAYREAKEKLGIETKPVLIGPYTFISLSKGFNKQEIPGIILSLLPLYTQILRELEQEGVKWVQMDEPSLVSSISKDDMQTVTYLYEKLNEAAPNLNIMLQTYFDAVEHYQEVIELQVQGIGLDFVHDKGRNLSNLEAFGFPKDKVLAAGVIDGKNIWLSDLSKKIQLIETLKKKVAEDQIWLQPSCSLLHVPVTVRNETALSKEVKEALAFADEKLEEITLLVKGNNQGFEAIAEKVDANKFTVQTLASSNARNHGSVQSNVEKVKTRTSGRQLPFKERYQKQQEFFKLPFLPSTTIGSFPQTLEVKQARGKFKRGEWTASQYETFVNEEIGRWIEIQEEIGLDVLVHGEFERTDMVEYFGHKLGGFVFLEKGWVQSYGSRCVKPPVIYGDIHFIEPMTVRESVYAQSLTKKTVKGMLTGPVTILNWSFVRDDTSRENVCYQLALALEKEVIALESAGIKMIQVDEPALREGLPLKKSDRDEYLNWAVNSFLISTSSVEDTTQIHTHMCYCDFNSFMDVISSLDADVISIETSRSHGELASAFEEKTYEKGIGLGVYDIHSPRVPAVEEMVDMIERGIKVLDKDQFWINPDCGLKTRGIPETVASLKNMVEAAKIVRENLLAKPTGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VNKI01000006
EMBL· GenBank· DDBJ
TVX80224.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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