A0A8B3MBY0 · A0A8B3MBY0_ECOLX

  • Protein
    2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
  • Gene
    mhpB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site115Proton donor
Active site179Proton acceptor

GO annotations

AspectTerm
Molecular Function3-carboxyethylcatechol 2,3-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process3-phenylpropionate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
  • EC number
  • Alternative names
    • 3-carboxyethylcatechol 2,3-dioxygenase

Gene names

    • Name
      mhpB
    • ORF names
      CIG67_02190

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CCPM 6219
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A8B3MBY0

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-309Extradiol ring-cleavage dioxygenase class III enzyme subunit B

Sequence similarities

Belongs to the LigB/MhpB extradiol dioxygenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    317
  • Mass (Da)
    34,238
  • Last updated
    2021-09-29 v1
  • Checksum
    B7ABC6392BEC1DB1
MHAYLHCLSHSPLVGYVDPAQAVLDEVNGVIASARARIAAFEPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPTDLAEACAHAVMKSGIDLAVSYNMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFASSLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKQLPENERELRQQRVISAAEKFVVDQNTLHPLNPVRDNRFMSLLEQGRLQGLDAVSNEELSAMAGKSTHEVKTWVAAFAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSATTQN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NPIM01000060
EMBL· GenBank· DDBJ
RVE16355.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp