A0A8A9WN45 · A0A8A9WN45_EUPAE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processoxidative phosphorylation
Biological Processrespiratory electron transport chain

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Spirotrichea > Hypotrichia > Euplotida > Euplotidae > Euplotes

Accessions

  • Primary accession
    A0A8A9WN45

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-44Helical
Transmembrane64-90Helical
Transmembrane102-129Helical
Transmembrane149-167Helical
Transmembrane279-302Helical
Transmembrane576-599Helical
Transmembrane620-643Helical
Transmembrane676-695Helical
Transmembrane707-725Helical
Transmembrane737-757Helical
Transmembrane769-791Helical
Transmembrane803-828Helical
Transmembrane840-862Helical
Transmembrane882-905Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-941Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    993
  • Mass (Da)
    117,583
  • Last updated
    2021-09-29 v1
  • Checksum
    FCD314CCB8693A89
MMCILFLLKSSINNWLLFKYIWMDYTSYVRFIKFFGLFNMRLLWQNRYLLYNWVYSTNHKRISINYFWFVLFAGVVGMVLATIIRIEMAYPGTGILAGDNSVYLSVVTAHGVVMVFFMAMPLLFGFLGNFLLPTQLGVHDVAFPRMNSAAFWFLPSSLLTLCQLVCVDRRYQRMNSFNIRELQSLLRNQFFFELNLPSLITTNKLTLLLLKYKLNNLTNILLPEMHTFYLLNYFTVLMTPWTIVSSYITNYWTYCYIYHITLFNYIYNFNWSFIINFNIISLVVAFFLNIKYLIFSYFWFFFDFKYINFFKFSLYTNTLYTNTLYTNTLYTNTLYTNTLYTNTLYTNTLYTNTLYTNKTLNFEQVLNNRNSLLKNPLCNYKIKIGNFLPDTLYQTNFSFLYTSLIAKVLNSYKANWFQSTTIITLLKKNYNYTITTDFINFNALNIFTNVKFSSNKLTSWDLLLYITIFNNNNFFYLNKFWLNNIYLNLNLLNLYFTQSKQNRILNNWRFLRLNREGWRCRMLVARFQRSLYYRHVNENELIWVVERNAKDLLPGWAMITPFASRTRYTLVGKTDVGITIVVVTLIASMISSANFLMTYRYLSTLNNRKMRDARCFFSESIIAASWMMIAANPMLILGLLMLLSDRHWKTSFFDYSGGGDTILFQHMFWFFGHPEVYIIIIPCFGVANTLMSFYLRKRISARASLMYSLYTIAFLGFFVWGHHMYMVGLAHTTRMLYSTLTVMISVPAATKIMHWLVTFVNSTMHFEMPFILTLLFIFYFVSGGISGMAIAHTGMNILFHDTFYIVGHFHVMLAGSLMFASYAAFYFYLPSLFGVRYSRLFAYLHVFYYSFGQLFTVVPMLWLGYLGMPRRVLDYPVAMGGWHSLTTAAHIITVSGILAFVLTLFDSLRKKKSYIIKTFGVGRYNTRLNFYLYQSARNYYWLMKHGTLLKIRPIQLLQSTSHLIWNFEIYESTLLYYSFIYSDIDIQKIKNDY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT665958
EMBL· GenBank· DDBJ
QTT61028.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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