A0A8A3NUB2 · A0A8A3NUB2_9HELO
- ProteinRNA polymerase II subunit A C-terminal domain phosphatase SSU72
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids260 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.
Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).
Catalytic activity
- O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mRNA cleavage and polyadenylation specificity factor complex | |
Molecular Function | RNA polymerase II CTD heptapeptide repeat phosphatase activity | |
Biological Process | mRNA processing | |
Biological Process | termination of RNA polymerase II transcription |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRNA polymerase II subunit A C-terminal domain phosphatase SSU72
- EC number
- Short namesCTD phosphatase SSU72
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Monilinia
Accessions
- Primary accessionA0A8A3NUB2
Proteomes
Subcellular Location
Interaction
Subunit
Component of the cleavage and polyadenylation factor (CPF) complex.
Structure
Sequence
- Sequence statusComplete
- Length260
- Mass (Da)28,674
- Last updated2021-09-29 v1
- MD5 Checksum0C36377B43C69DAFB7BE097D4B4610E3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-20 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP063405 EMBL· GenBank· DDBJ | QSZ29285.1 EMBL· GenBank· DDBJ | Genomic DNA |