A0A8A0RI04 · A0A8A0RI04_9FIRM

Function

function

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

Caution

Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site46Part of a proton relay during catalysis
Binding site47pyruvate (UniProtKB | ChEBI)
Site107Part of a proton relay during catalysis
Active site133Proton donor/acceptor
Active site161Schiff-base intermediate with substrate
Binding site203pyruvate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate synthase activity
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate synthase
  • EC number
  • Short names
    HTPA synthase

Gene names

    • Name
      dapA_1
    • Synonyms
      dapA
    • ORF names
      H0A61_00150

Organism names

Accessions

  • Primary accession
    A0A8A0RI04

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer; dimer of dimers.

Family & Domains

Sequence similarities

Belongs to the DapA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    292
  • Mass (Da)
    31,979
  • Last updated
    2022-01-19 v1
  • Checksum
    49B12A89C75DB58C
MVEWGRLITAMVTPFDENLKVDYDKAVEIARYLVKEGSTALVVGGTTGEAPTLTDEEKLELFKVLKEKVDVPIIAGVGTNSTEKTIKLSKRVMECGVDGIMAVVPYYNKPNQEGIYRHFKAIAENVNLPVMLYNVPGRTGANMAFETVIRLSKISNIIALKEAGGDLDQAGRVLRGVDRDFKVYSGDDSLTLPMLSIGCYGVVSVASHVVGRKMREMIDSYLAGRVDEAAQIHLSLLPIFRDLFITANPIPVKAALRLAGYDPGSLRLPLVEADEKVVEVLKNDLKELGIIE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP059066
EMBL· GenBank· DDBJ
QSQ07833.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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