A0A883EUB0 · A0A883EUB0_9TELE

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Serranoidei > Serranidae > Serraninae > Serranus

Accessions

  • Primary accession
    A0A883EUB0

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-53Helical
Transmembrane74-98Helical
Transmembrane118-141Helical
Transmembrane153-180Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-207Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    207
  • Mass (Da)
    22,218
  • Last updated
    2021-09-29 v1
  • Checksum
    89CA1635647938CB
TALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAISQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue207

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MW439283
EMBL· GenBank· DDBJ
QQK89392.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439284
EMBL· GenBank· DDBJ
QQK89393.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439285
EMBL· GenBank· DDBJ
QQK89394.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439286
EMBL· GenBank· DDBJ
QQK89395.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439287
EMBL· GenBank· DDBJ
QQK89396.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439288
EMBL· GenBank· DDBJ
QQK89397.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439289
EMBL· GenBank· DDBJ
QQK89398.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439290
EMBL· GenBank· DDBJ
QQK89399.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439291
EMBL· GenBank· DDBJ
QQK89400.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439292
EMBL· GenBank· DDBJ
QQK89401.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439293
EMBL· GenBank· DDBJ
QQK89402.1
EMBL· GenBank· DDBJ
Genomic DNA
MW439294
EMBL· GenBank· DDBJ
QQK89403.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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