A0A873HUW2 · A0A873HUW2_9EUTH

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      ND4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Scandentia > Tupaiidae > Tupaia

Accessions

  • Primary accession
    A0A873HUW2

Subcellular Location

Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-43Helical
Transmembrane63-82Helical
Transmembrane94-110Helical
Transmembrane116-136Helical
Transmembrane148-167Helical
Transmembrane194-216Helical
Transmembrane223-244Helical
Transmembrane256-277Helical
Transmembrane284-303Helical
Transmembrane309-330Helical
Transmembrane351-373Helical
Transmembrane393-414Helical
Transmembrane435-454Helical

Keywords

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-109NADH:ubiquinone oxidoreductase chain 4 N-terminal
Domain112-399NADH:quinone oxidoreductase/Mrp antiporter transmembrane

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    51,948
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    38192A8486F027D449CF476ED26D796D
MLKIILPTAMLMPLTWLSKNNMIWINTTMHSLLISLVSLSMFYQMMDTGLNFSLNFFSDSLSTPLLILTTWLLPLMIMASQNHLNKEPITRKKLYISMLVLLQFFLIMTFTATELILFYILFEATLIPTLIIITRWGNQTERLNAGTYFLFYTLLGSLPLLVALVYLQNTTGTLNFPLMALTHKSLTPSWSNNLLWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRISVVLEPLTKTMAYPFMILSLWGMIMTSAICLRQTDLKSLIAYSSVSHMALVVAAIMIQTPWSYMGATMLMIAHGLTSSVLFCLANSNYERIHSRTMLLARGLQTVLPLMAFWWLLASLSNLALPPSINLMGEMLVIMSTFAWSNFTITLMGLNMLITALYSFYMLITTQRGKFTHHINNIKPSFTRENSLMLMHLVPLFLLMLKPNIIMGPTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT423930
EMBL· GenBank· DDBJ
QOZ41295.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423931
EMBL· GenBank· DDBJ
QOZ41308.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423932
EMBL· GenBank· DDBJ
QOZ41321.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423933
EMBL· GenBank· DDBJ
QOZ41334.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423934
EMBL· GenBank· DDBJ
QOZ41347.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423935
EMBL· GenBank· DDBJ
QOZ41360.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423936
EMBL· GenBank· DDBJ
QOZ41373.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423937
EMBL· GenBank· DDBJ
QOZ41386.1
EMBL· GenBank· DDBJ
Genomic DNA
MT423939
EMBL· GenBank· DDBJ
QOZ41412.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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