A0A859GUJ3 · A0A859GUJ3_SARS2

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site6015
Active site6017
Active site6116
Active site6193
Active site6198
Binding site6256-6262S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site6686
Active site6701
Active site6741

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum-Golgi intermediate compartment
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Function3'-5'-RNA exonuclease activity
Molecular Function5'-3' DNA helicase activity
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionendonuclease activity
Molecular FunctionG-quadruplex RNA binding
Molecular Functionlyase activity
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionomega peptidase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionsingle-stranded RNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processinduction by virus of host autophagy
Biological Processproteolysis
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral protein processing
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ORF1ab polyprotein

Gene names

    • Name
      ORF1ab

Organism names

Accessions

  • Primary accession
    A0A859GUJ3

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2229-2253Helical
Transmembrane2345-2369Helical
Transmembrane2773-2791Helical
Transmembrane3043-3065Helical
Transmembrane3077-3098Helical
Transmembrane3136-3154Helical
Transmembrane3582-3605Helical
Transmembrane3611-3629Helical
Transmembrane3636-3657Helical
Transmembrane3683-3701Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond2282↔2288

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain12-127CoV Nsp1 globular
Domain148-179BetaCoV Nsp1 C-terminal
Domain183-456CoV Nsp2 N-terminal
Domain458-688CoV Nsp2 middle
Domain690-818CoV Nsp2 C-terminal
Domain821-929Ubiquitin-like
Region926-1000Disordered
Compositional bias927-947Acidic residues
Compositional bias984-1000Polar residues
Domain1025-1194Macro
Domain1231-1359Macro
Domain1367-1494Macro
Domain1496-1561DPUP
Domain1565-1620Ubiquitin-like
Domain1634-1898Peptidase C16
Domain1911-2021Nucleic acid-binding
Domain2046-2155G2M
Domain2247-23173Ecto
Region2463-2485Y1
Domain2463-2763CoV Nsp3 Y
Region2486-2580Y2
Region2486-2763CoV-Y
Region2581-2662Y3
Region2663-2763Y4
Domain3165-3263Nsp4C
Domain3264-3569Peptidase C30
Domain3860-3942RdRp Nsp7 cofactor
Domain3943-4140RdRp Nsp8 cofactor
Domain4141-4253Nsp9 ssRNA-binding
Domain4254-4392ExoN/MTase coactivator
Domain4399-4653NiRAN
Domain4658-4756Nsp12 Interface
Domain4757-5324Nsp12 RNA-dependent RNA polymerase
Domain5004-5166RdRp catalytic
Domain5325-5408CV ZBD
Domain5581-5932+RNA virus helicase C-terminal
Domain5997-6212ExoN
Domain6221-6452N7-MTase
Region6339-6353GpppA-binding
Domain6453-6513Nsp15 N-terminal oligomerization
Domain6514-6639AV-Nsp11N/CoV-Nsp15M
Domain6656-6795NendoU
Domain6800-7094Nidovirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    7,096
  • Mass (Da)
    793,907
  • Last updated
    2021-09-29 v1
  • Checksum
    2E97B46BB461BD85

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias927-947Acidic residues
Compositional bias984-1000Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT635245
EMBL· GenBank· DDBJ
QKV25595.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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