A0A858E7G0 · GGDPS_MELLP

Function

function

Geranylgeranyl pyrophosphate synthase that catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate (PubMed:32913319).
Does not show any monoterpene nor sesquiterpene synthase activity (PubMed:32913319).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site77isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site80isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site109isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site116Mg2+ 1 (UniProtKB | ChEBI)
Binding site116Mg2+ 2 (UniProtKB | ChEBI)
Binding site120Mg2+ 1 (UniProtKB | ChEBI)
Binding site120Mg2+ 2 (UniProtKB | ChEBI)
Binding site125dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site126isopentenyl diphosphate (UniProtKB | ChEBI)
Site148Important for determining product chain length
Binding site210dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site211dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site246dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site249Mg2+ 3 (UniProtKB | ChEBI)
Binding site253dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site262dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site272dimethylallyl diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Molecular Functionprenyltransferase activity
Biological Processisoprenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Geranylgeranyl pyrophosphate synthase
  • EC number
  • Short names
    GGPP synthase
    ; GGPPSase
  • Alternative names
    • (2E,6E)-farnesyl diphosphate synthase
    • Dimethylallyltranstransferase
      (EC:2.5.1.1
      ) . EC:2.5.1.1 (UniProtKB | ENZYME | Rhea)
    • Farnesyl diphosphate synthase
    • Farnesyltranstransferase
      (EC:2.5.1.29
      ) . EC:2.5.1.29 (UniProtKB | ENZYME | Rhea)
    • Geranylgeranyl diphosphate synthase
    • Geranyltranstransferase
      (EC:2.5.1.10
      ) . EC:2.5.1.10 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      GGDPS
    • ORF names
      MELLADRAFT_47465

Organism names

Accessions

  • Primary accession
    A0A858E7G0
  • Secondary accessions
    • F4RDE7

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004571501-364Geranylgeranyl pyrophosphate synthase

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region1-34Disordered
Compositional bias20-34Polar residues
Motif116-120DDXXD 2

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    41,198
  • Last updated
    2021-09-29 v1
  • Checksum
    172BE22D341F3076
MKPVPSTNGKVDDKVEHHNLSSSSSSSSSSSSSDTKFNISNRYGNFLQRLEALDIWPESNEQILLEPYTYLTNIPGKEIRSMMIDAFNHWLQVPRPALEIIKKIVGQLHTASLLMDDVEDDSDLRRGVPVTHKIYGIPQTINTANYVYFLAYQELTKLKPCLRSDATTDLWSLVNDELLQLHRGQGMDLYWRDSLTCPTEEEYLQMVNNKTGGLFRIAIKLMIALSPIPETPDYLPLVNLVGIIFQIRDDLLNLSSVYTKNKGFCEDLTEGKFSFPIVHSIRSDSTNHQLMNILRQKPTDIGTKAFAVSYMKDRTKSLEYTRGVLICLEEQAIEEVTRLGGNPALESIFELMHVLPSPPATDQN

Sequence caution

The sequence EGG09623.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias20-34Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL883097
EMBL· GenBank· DDBJ
EGG09623.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
MK946437
EMBL· GenBank· DDBJ
QIG55789.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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