A0A855MLG0 · A0A855MLG0_9BACT

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site12-14N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site64(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site89-92(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site106(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site108Proton donor
Site144Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      AA80_09700

Organism names

Accessions

  • Primary accession
    A0A855MLG0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-181Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    22,449
  • Last updated
    2021-09-29 v1
  • Checksum
    586CF1562482433A
MKKIVILASGNGTNFEAICKYFSNSSKISIIKLITDNKKAYVIERAKRLGIDYEIIDYTTFKSKKEYNDYLFGRLKDLDSDLIVLAGYMKILPGYIVRYYANRIINIHPSLLPKYPGLRSIERAFNNKEEYTGITIHYVEEKVDDGRIILQKELKVEKNWDLEKLEEEIHKLEHQYYPKVVEELLNNSDEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHC01000040
EMBL· GenBank· DDBJ
POZ87818.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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