A0A855JMR4 · A0A855JMR4_9PSED

Function

function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 zinc ions per subunit.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site21substrate
Binding site51Zn2+ 1 (UniProtKB | ChEBI)
Binding site55Zn2+ 1 (UniProtKB | ChEBI)
Binding site57Zn2+ 1 (UniProtKB | ChEBI)
Binding site57Zn2+ 2 (UniProtKB | ChEBI)
Active site61Proton donor/acceptor
Binding site163Zn2+ 2 (UniProtKB | ChEBI)
Binding site175Zn2+ 2 (UniProtKB | ChEBI)
Binding site175Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionarylformamidase activity
Molecular Functionformamidase activity
Molecular Functionzinc ion binding
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynurenine formamidase
  • EC number
  • Short names
    KFA
    ; KFase
  • Alternative names
    • Arylformamidase
    • N-formylkynurenine formamidase
      (FKF
      )

Gene names

    • Name
      kynB
    • ORF names
      C1Y25_32105

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MPBC4-3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A855JMR4

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the Cyclase 1 superfamily. KynB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    23,621
  • Last updated
    2021-09-29 v1
  • Checksum
    55DAA5DF929A1624
MNPIKTWWDISPPLSAATPTWPGDTPFQEERVWQFGPECPVNVGRITLSPHTGAHVDAPLHYSAQGAPIGEVSLDVYMGPCRVLHCLDSGALVQPHQLDGRVDNLPERVLLRTYPQAPLTEWDSNFTAIAPQTIELLAGLGVRLIGIDTPSLDPQQSKTMDAHNAVARHGMAILEGIVLDDVAEGDYELIALPLRFAHLDASPVRAILRPLKEPTR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
POFS01000167
EMBL· GenBank· DDBJ
PMX03334.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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