A0A853MEB9 · A0A853MEB9_9CYAN
- Protein5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase
- GenecofH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids399 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
Catalytic activity
- 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine
Cofactor
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Pathway
Cofactor biosynthesis; coenzyme F0 biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity | |
Molecular Function | iron ion binding | |
Molecular Function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Aphanizomenonaceae > Cylindrospermopsis
Accessions
- Primary accessionA0A853MEB9
Proteomes
Interaction
Subunit
The FO synthase complex consists of two subunits, CofG and CofH.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 58-285 | Radical SAM core | ||||
Sequence: VTYVINRNINFTNICEQHCSFCAFRRDDSDEDAYWLDWSQILEKSADAVSRGATEICMQGGLNPKAQIHGKSLLYYIKLIETIKQNFPQLHIHAFSPQEIQFIAKLDSISYEQVITDLRDVGLGSIPGTAAEVLDDEVRKVLCPEKINTSTWLEIVTTAHQLGLCTTSTMLSGHIETPEQQITHLEKLRQLQQAAHEKEYPGQITEFILLPFVGQDVPKPLRRRVGRD |
Sequence similarities
Belongs to the radical SAM superfamily. CofH family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length399
- Mass (Da)44,789
- Last updated2021-09-29 v1
- Checksum8FEB691FAA9B5FDF