A0A853MEB9 · A0A853MEB9_9CYAN

Function

function

Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; coenzyme F0 biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site72[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site76[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site79[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
Molecular Functioniron ion binding
Molecular Functiontransferase activity, transferring alkyl or aryl (other than methyl) groups

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase
  • EC number
  • Alternative names
    • FO synthase subunit 2

Gene names

    • Name
      cofH
    • ORF names
      A9P98_03590

Organism names

Accessions

  • Primary accession
    A0A853MEB9

Proteomes

Interaction

Subunit

The FO synthase complex consists of two subunits, CofG and CofH.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain58-285Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. CofH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    399
  • Mass (Da)
    44,789
  • Last updated
    2021-09-29 v1
  • Checksum
    8FEB691FAA9B5FDF
MNNITLTPINPILERSLLGSDISPSEAVILLKQTDPETINIIRETADKLRQKQAGEEVTYVINRNINFTNICEQHCSFCAFRRDDSDEDAYWLDWSQILEKSADAVSRGATEICMQGGLNPKAQIHGKSLLYYIKLIETIKQNFPQLHIHAFSPQEIQFIAKLDSISYEQVITDLRDVGLGSIPGTAAEVLDDEVRKVLCPEKINTSTWLEIVTTAHQLGLCTTSTMLSGHIETPEQQITHLEKLRQLQQAAHEKEYPGQITEFILLPFVGQDVPKPLRRRVGRDQPILADALLLTAVARIFLGKYIPNHQPSWVKLGLTGAMEALNWGCNDIGGTLMEEHITTMAGAIGGTCMEVETLQNAILSLNRPYQQRNTLYVRLSPDFNNREKSIPEYQSKIG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LYXA01000001
EMBL· GenBank· DDBJ
OBU75498.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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