A0A853MDB5 · A0A853MDB5_9CYAN

Function

function

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Pathway

Cofactor biosynthesis; phylloquinone biosynthesis.
Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.

GO annotations

AspectTerm
Molecular Function2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionthiamine pyrophosphate binding
Biological Processmenaquinone biosynthetic process
Biological Processphylloquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
  • EC number
  • Short names
    SEPHCHC synthase

Gene names

    • Name
      menD
    • ORF names
      A9P98_14715

Organism names

Accessions

  • Primary accession
    A0A853MDB5

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-127Thiamine pyrophosphate enzyme N-terminal TPP-binding
Domain220-406Menaquinone biosynthesis protein MenD middle

Sequence similarities

Belongs to the TPP enzyme family. MenD subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    578
  • Mass (Da)
    65,107
  • Last updated
    2021-09-29 v1
  • Checksum
    959B299949853BB0
MHLVFKNVNQLWSYVVVSTLKHLGLDFAILCPGSRSTPLTLAFCQEGSDIESIAILDERSGAFFALGRAKATRKPVVLVCTSGTAGANFYPAVIEAKESCVPLLLLTADRPPELRDCHSGQTIDQVKLYGNYPNWQTELATPLAEIQMLGYLRQTIIHAWKRCQFPRGGVVHLNIPFRDPLAPVADGTDFILDTEEFFRGIIPTPLPTVNYPLPLEWKKYERGIIIAGVAQPQDPEKYCQAISCLSRTLQWPVLAEGLSPVRNYADLCPYLISTYDLILRNPQLRQELTPQIIIQIGEMPTSKELRHWLVEVNAQRFVIDSSFENIDPLHGKTVHLRISVEDLDFGGVWDSMANLCLQQYLQQWCAIEAAVRKNIDDMFLKTEELTESKAAWLISQLLPANTPLFIANSMPVRDVEFFWKPNSLRIKPYFNRGANGIDGSISTALGIAHQHHTSLGSIMLTGDLALLHDTNGFLLRNKFLGHLTIVLINNNGGGIFEMLPIANFDPPFEDFFATPQNINFADLCVTYGVDYELISSWHQLEERLRILPSQGIRVLEIPTNRKRDAQWRKQCLGKMSLL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LYXA01000001
EMBL· GenBank· DDBJ
OBU77390.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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