A0A852MQQ7 · A0A852MQQ7_9PASS

  • Protein
    Flavin-containing monooxygenase 5
  • Gene
    Fmo5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (2E)-geranial + NADPH + O2 + H+ = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • N,N-dimethylaniline + NADPH + O2 + H+ = N,N-dimethylaniline N-oxide + NADP+ + H2O
    This reaction proceeds in the forward direction.
    EC:1.14.13.8 (UniProtKB | ENZYME | Rhea)
  • octan-3-one + NADPH + O2 + H+ = pentyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = ethyl hexanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • sulcatone + NADPH + O2 + H+ = 4-methylpent-3-en-1-yl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • NADPH + O2 + H+ = H2O2 + NADP+
    This reaction proceeds in the forward direction.
    EC:1.6.3.1 (UniProtKB | ENZYME | Rhea)
  • heptan-2-one + NADPH + O2 + H+ = pentyl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • heptan-4-one + NADPH + O2 + H+ = propyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = propyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = ethyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNADP binding
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase 5
  • EC number
  • Alternative names
    • Dimethylaniline monooxygenase [N-oxide-forming] 5
    • Dimethylaniline oxidase 5
    • NADPH oxidase

Gene names

    • Name
      Fmo5
    • ORF names
      PTEMEL_R09220

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • B10K-IZ-033-77
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Sylvioidea > Timaliidae > Pteruthius

Accessions

  • Primary accession
    A0A852MQQ7

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane510-533Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Sequence similarities

Belongs to the FMO family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    535
  • Mass (Da)
    60,278
  • Last updated
    2021-09-29 v1
  • Checksum
    E81B91C619C29490
MAAQRVAIIGAGASGLCALKCCLDEGLEPTCFERSKDIGGLWRFEEHPEDGRASIYRSVIINTSKEMMCFSDFPIPADFPNYMHNSKIMEYFRMYAQHFDLLRHIRFRTSVCRVSKRPDFARSGQWEVVTESEGKQETAVFDAVLVCSGHHTDAHLPLSSFPGLEKFEGWYLHSRDYKSPQPFLGKQVVVVGIGNSGIDIAVELSHAAKQVFLSTKRGSWVLHRVADSGYPADFSYISRFTQLFRSLLPPNIISFLVERKLNTRFDHTLYGLKPKHRVLDQHPTVNDDLPNRILSGRVRVKPNIQEFTETSAIFEDGTRENVDAVVFATGYSFSFPFLEGFKVVENQIPLYKFVFPSYLEKPTLAFIGFIQPLGAIMPISELQCRWATHVFKGLQGLPPPADMLAEITQTKERMAERYVKSQRHTIQVDYIPYMDELACQLGVKPNVLTLFLTDPKLALEVVFGPCTPYQYRLRGPGAWAGAREAILTQRQRVVRALQPRASGRPARSSAAPHVLTVLFSIGMIAATLVYVSLSS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue535

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WEIY01000146
EMBL· GenBank· DDBJ
NXY04049.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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