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A0A852MM56 · A0A852MM56_9PASS

  • Protein
    Aminopeptidase
  • Gene
    Enpep
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
    EC:3.4.11.7 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

1940100200300400500600700800900
Type
IDPosition(s)Description
Binding site215substrate
Binding site349-353substrate
Binding site385Zn2+ (UniProtKB | ChEBI); catalytic
Active site386Proton acceptor
Binding site389Zn2+ (UniProtKB | ChEBI); catalytic
Binding site408Zn2+ (UniProtKB | ChEBI); catalytic
Site471Transition state stabilizer
Binding site875substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functionmetalloaminopeptidase activity
Molecular Functionpeptide binding
Molecular Functionzinc ion binding
Biological Processpeptide catabolic process
Biological Processproteolysis
Biological Processregulation of blood pressure

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminopeptidase
  • EC number

Gene names

    • Name
      Enpep
    • ORF names
      PTEMEL_R14319

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • B10K-IZ-033-77
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Sylvioidea > Timaliidae > Pteruthius

Accessions

  • Primary accession
    A0A852MM56

Proteomes

Subcellular Location

Cell membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-38Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer; disulfide-linked.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region38-65Disordered
Compositional bias45-61Polar residues
Domain90-278Aminopeptidase N-like N-terminal
Domain313-530Peptidase M1 membrane alanine aminopeptidase
Domain605-921ERAP1-like C-terminal

Sequence similarities

Belongs to the peptidase M1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    940
  • Mass (Da)
    108,044
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    9C99B75E9834A091CDC7CBE6922E6645
MDFEDEKSKRYCMKTKHVAIICGVVVIVGLAVGLGVGLSRPKPPKATEQPTTDQMTTTDQPPPPVDLGPCPSKDDETGDWRNFRLPTYVKPIHYDLEIKPEMEKDTYSGTVSISIALEKPTSSLWLHLRETKVTETPTLRKSSGQQIALNDCFEYKPQEYIVMKAAAELPVTDESDPYVLTLKFQGWLNGSLVGFYRTTYIENGQIKSIAATDHEPTDARKSFPCFDEPNKKATYNISIIHQDVYQALSNMPVQQTVQLGDGWNRTTFEKSVPMSTYLVCFAVHQFAWVERISDSGKPLRVYVQPQQIHTAQYAANVTKNVFDFFERYFNLSYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESATSNKQRVAAVIAHELVHQWFGNIVTMDWWDDLWLNEGFASYFEFLGANATEPEWQMLEQVLIDDVLPVLKDDSLLSSHPIVVDVSSPAEITSVFDGISYSKGASILRMVRDWITPDLFQKGCQAYLKKYHFQNAKTQQFWEALEEASNKPVKEVMDTWTRQMGYPVLEMGDNSVFTQKRFLLDPNANASHPPSDLGYKWNIPVKWKLGNSSNYAFYNASDSTGITIATSPDNFLNVNPDHIGFFRVNYDSQNWARLSTLLLQNHKSFSSADRAGILDDAFSLARPGLVNYAVPLELTKYLRNETEYLPWHRVVSAVTYLANMLEDDTNLYPLFQRHFRNLVKPIVDQLGWEDSGDHLQRLLRASVLDFACSMNDTESLNNASQLFNRWLQGETIAANLRLIVYRYGMQNSGNETSWNYMFNKYQETSLAQEKEKLLYGLASVRNITLLDRYLKYIYNTSLIKSQDVFTVLRYISYNTYGKTMAWDWIRLNWQYLIDRFTINDRTFGRIVTIAQTYNTELQLWQMENFFEKYPNAGAGELPRSQSLEQVKSNIKWLKENKEEIQTWLEA

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias45-61Polar residues
Non-terminal residue940

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WEIY01000252
EMBL· GenBank· DDBJ
NXY05370.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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