A0A849R5K7 · A0A849R5K7_9GAMM

  • Protein
    ATP-dependent zinc metalloprotease FtsH
  • Gene
    hflB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

163350100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site193-200ATP (UniProtKB | ChEBI)
Binding site416Zn2+ (UniProtKB | ChEBI); catalytic
Active site417
Binding site420Zn2+ (UniProtKB | ChEBI); catalytic
Binding site494Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      hflB
    • Synonyms
      ftsH
    • ORF names
      HOP36_07670

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WB-IL-21
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Methylococcales > Methylococcaceae > Methyloglobulus

Accessions

  • Primary accession
    A0A849R5K7

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane5-25Helical
Transmembrane100-121Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain185-325AAA+ ATPase
Region593-633Disordered
Compositional bias603-633Polar residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    633
  • Mass (Da)
    69,387
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    81736CE8BB52CFA80988E09DC4B3C663
MKRYILNTLLWSVVFTGAFLIYNRINATPPIQDSLAYSEFIAKVKGGQVDRVEISGQSIKVRTSDGQNLQTFNPGDQHLIDDLLSADVQIRTIPPAQQSMMMQIFISWFPMLLLIVVWIVYMRRTQGGAGGAGQFGKSKAKMLEEDKLTVKFADVAGCEEAKEEVSELVDFLRDPQKFQKLGGMIPRGILMVGPPGTGKTLLARAIAGEAGVKFFTISGSDFVEMFVGVGASRVRDMFAQAKEHAPCIIFIDEIDAVGRQRGGAGMGGGNDEREQTLNQLLVEMDGFTGNEGVIIIAATNRADVLDKALLRPGRFDRQVTVGLPDVKGREQILNVHIKKVPIGDDVELKNIARGTPGFSGADLANIINEAALLAARSNKQKVGMNELEKAKDKILMGAEKHTMVMSEDDKRLTAYHEAGHCIVGQMSPDHDPVYKVSIMPRGRALGITMFLPERDQYSASKRKLESQIASLFGGRIAELMIYGGDRVTTGASNDIERATELARNMVTRWGFSDIMGPLVYGEEGGQPFMGYSASGSKVSNSVQDKIDEEIRFVIDKNYKKAETLLQDNISILHKMADALMKWETIDKAQIDDLMAGKDPKPPVDNNDSSNKPDITPKQDTTPNTNLTKPAGQV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias603-633Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABFSV010000230
EMBL· GenBank· DDBJ
NOS74402.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help