A0A849GNP1 · A0A849GNP1_9GAMM

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site119ATP (UniProtKB | ChEBI)
Binding site203ATP (UniProtKB | ChEBI)
Active site296
Binding site543Mn2+ (UniProtKB | ChEBI)
Binding site615substrate
Binding site712Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site741Mn2+ (UniProtKB | ChEBI)
Binding site743Mn2+ (UniProtKB | ChEBI)
Binding site876substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • Name
      pyc
    • ORF names
      HKO73_15915

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Site_A33
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Woeseiales > Woeseiaceae

Accessions

  • Primary accession
    A0A849GNP1

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue712N6-carboxylysine
Modified residue1113N6-biotinyllysine

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-456Biotin carboxylation
Domain123-321ATP-grasp
Domain534-802Pyruvate carboxyltransferase
Domain1072-1147Lipoyl-binding

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,148
  • Mass (Da)
    126,278
  • Last updated
    2021-09-29 v1
  • Checksum
    16183DFE206743EA
MAEFNKILVANRGEIAIRVMRAANELGKKTVAVYAEEDKLGLHRFKSDQAYRIGEGMGPVAAYLSIEEIIRVAIHSGADAIHPGYGLLSENPMFVDACDAAGIKFIGPKAETMRQLGDKASARRVAIEAGVPVVPASDILPDDPAEIRRMAAEVGYPLMLKASWGGGGRGMRAIMSADELQEKVLEGRREAEAAFGNGEGYVERLVQRARHVEVQILGDRHGDIYHLWERDCSVQRRNQKVVERAPAPYLSQSQRDYICSLGIKVCAHVGYECAGTVEFLMDMDTDEFFFIEVNPRVQVEHTVTEEITGIDIVSAQIRIAEGATLAEATGANTQQDVPLNGHALQCRITTEDPQNNFIPDYGRLLAYRAATGMGIRLDGGTAYNGATITRYYDSLLEKVTAWAPTEKAAIARMDRALREFRIRGVSTNIAFVENLLRHPTFLNNTYSTKFIDNTPELFEFRKRRDRATKLLTYIADISLNGHPETAGRERPTGKVKAACAPANRFDTPAYGSRNLLEEKGPQAVADWMHAQKQLLITDTTMRDAHQSLLATRMRSLDMINIAETYAHNLPQLFSIECWGGATFDVAYRFLQECPWQRLRDLREKIPNIMTQMLLRASNGVGYTNYPDNVVQEFVRQAAVSGVDVFRVFDSLNWVENMRVAMDAVIANDKLCEGTICYTGDILDPNRAKYNLKYYVDMAKQLEAAGAHVLGLKDMAGLLKPAAATVLIKALKEEIGLPIHFHTHDTSGIAGATILAASAAGVDAADVAMDAFSGGTSQACMGSVVEALRNTERDTGLDIKAIREVSNYWEGVRAQYSAFESGLAAPASEVYLHEMPGGQFTNLKAQARSLGLEDRWHEVAQTYADVNHMFGDIVKVTPSSKVVGDMALMMVSQGLTRAEVEDPATDVAFPDSVVDMMRGNLGQPPGGFPPGFQAKVLKDEVPITTRPGAHMDPVDLTGVRTDLCKQLEGYDVDSEDLNGYLMYPKVFLDYMGRRRRYGPVRTLPTRNFFYGMAPEEEISVEIDPGKTLEIRMQAVGETDEAGEAKVFFELNGQPRSIRVANRKATATTTRRVKAQENNPAHVGAPMPGVITSVLVTPGQQVKAGDLLLTMEAMKMETGVHAEHDAIVKQVHAPSGSQVDAKDLLLEFDA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABDOP010000267
EMBL· GenBank· DDBJ
NNL52288.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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